Bcl-2 immunohistochemistry in a surgical series of non-small cell lung cancer patients

Human Pathology
M V FlemingW D Travis

Abstract

The bcl-2 gene is implicated in oncogenesis by its ability to prolong cell survival through the inhibition of apoptosis, without increasing cell proliferation. An association between immunohistochemical staining for bcl-2 protein and the histological type and prognosis of non-small cell carcinoma was hypothesized by Pezzella et al. (N Engl J Med 329:690-694, 1993). In a case series, we stained formalin-fixed, paraffin-embedded tumor tissue from 106 surgical non-small cell lung cancer patients with an antibody to bcl-2 protein (DAKO clone 124, Carpinteria, CA). The resulting bcl-2 staining data were evaluated for associations with demographic, histological, immunohistochemical, and genetic features, including p53 mutations. Bcl-2 staining was observed in tumors from 29 of 106 (27%) of subjects, but was significantly less frequent in subjects' adenocarcinoma histology (8 of 55, 14.6%) (P = .007). This finding persisted after adjustment for age, gender, stage, grade, smoking history, and disease-free survival. In univariate analyses, no association was seen with age, weight, body mass index, gender, or pack-years smoking; tumor grade, stage, or patient performance status; p53 or c-erbB2 immunohistochemical staining, or p53 mutatio...Continue Reading

References

Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Apr 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M C Willingham, K Bhalla
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·J J RyanM F Clarke
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·M LamC W Distelhorst
Jun 16, 1994·The New England Journal of Medicine·S A McLachlan, M Stockler
Apr 15, 1994·Cancer·J F KerrB V Harmon
Jan 20, 1994·The New England Journal of Medicine·H R Katz
Jan 1, 1994·The Journal of Cell Biology·J C Reed
Jan 2, 1993·International Journal of Cancer. Journal International Du Cancer·Q L LuJ A Thomas
Sep 2, 1993·The New England Journal of Medicine·F PezzellaD Y Mason

❮ Previous
Next ❯

Citations

Mar 31, 2007·Histopathology·J SingtonK C Gatter
Jun 30, 2006·International Journal of Clinical Practice·A YarenM Alakavuklar
Dec 23, 1998·Cancer Treatment Reviews·R DziadziuszkoJ Jassem
Aug 9, 2001·International Journal of Cancer. Journal International Du Cancer·S RorkeS C Tang
Feb 26, 2000·Carcinogenesis·J W Gray, C Collins
Sep 29, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·W HilbeE Wöll
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Karim Vermaelen, Romain Pauwels
Oct 4, 2002·Oncogene·Ana I RoblesCurtis C Harris
Oct 10, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·E J GarciaC Cohen
Jan 7, 2004·Clinical Lung Cancer·Eelco FokkemaElisabeth G E de Vries

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.