Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Grace CallagyCarlos Caldas

Abstract

Prognostication of breast cancer using clinicopathologic variables, although useful, remains imperfect. Many reports suggest that gene expression profiling can refine the current approach. Alternatively, it has been shown that panels of proteins assessed by immunohistochemistry might also be useful in this regard. We evaluate the prognostic potential of a panel of markers by immunohistochemistry in a large case series to establish if either a single marker or a panel could improve the prognostic power of the Nottingham Prognostic Index (NPI). We validated the results in an independent series. The expression of 13 biomarkers was evaluated in 930 breast cancers on a tissue microarray. Eight markers [estrogen receptor (ER), progesterone receptor (PR), Bcl-2, cyclin E, p53, MIB-1, cytokeratin 5/6, and HER2] showed a significant association with survival at 10 years on univariate analysis. On multivariate analysis that included these eight markers and the NPI, only the NPI [hazard ratio (HR), 1.35; 95% confidence interval (95% CI), 1.16-1.56; P = 0.0005], ER (HR, 0.59; 95% CI, 0.39-0.88; P = 0.011), and Bcl-2 (HR, 0.68; 95% CI, 0.46-0.99; P = 0.055) were significant. In a subsequent multivariate analysis that included the NPI, ER, a...Continue Reading

References

Jan 1, 1992·Breast Cancer Research and Treatment·M H GaleaI O Ellis
Mar 1, 1982·British Journal of Cancer·J L HaybittleK Griffiths
Apr 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P P RosenL Norton
Oct 2, 1997·The New England Journal of Medicine·J RagazI A Olivotto
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C CharpinC Allasia
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Aug 8, 1998·The Journal of Surgical Research·K KnowltonB O Anderson
Nov 12, 1998·Journal of the National Cancer Institute·A GoldhirschH J Senn
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·P L FitzgibbonsS J Schnitt
Aug 30, 2000·Nature·C M PerouD Botstein
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P MalmströmUNKNOWN South Sweden Breast Cancer Group
Apr 6, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G D'Eredita'F Ferrarese
May 25, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R S RampaulUNKNOWN Nottingham Breast Team
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Dec 6, 2001·The American Journal of Pathology·J TorhorstG Sauter
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Feb 8, 2002·Nature·Carlos Caldas, Samuel A J Aparicio
Nov 15, 2002·The New England Journal of Medicine·Khandan KeyomarsiSarah S Bacus
Dec 6, 2002·The American Journal of Pathology·Matt van de RijnPat Brown
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Feb 27, 2003·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Grace CallagyCarlos Caldas
Oct 17, 2003·Life Sciences·Dao-Hai ZhangEvelyn Siew-Chuan Koay
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A GonzalezNicholas Coleman
Aug 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Patrik EdénCarsten Peterson
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikita A MakretsovC Blake Gilks
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Feb 22, 2005·Lancet·Tor-Kristian Jenssen, Eivind Hovig
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James D BrentonCarlos Caldas

❮ Previous
Next ❯

Citations

Jan 29, 2010·Breast Cancer Research and Treatment·Emad A RakhaIan O Ellis
Aug 4, 2010·Breast Cancer Research and Treatment·Ensaf M Al-HujailyAbdelilah Aboussekhra
Feb 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eramah ErmiahYrjö Collan
Jun 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sheng GaoCheng Lu
Aug 25, 2009·Nature Reviews. Cancer·Elizabeth A Musgrove, Robert L Sutherland
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Samantha R OakesGeoffrey J Lindeman
May 31, 2008·BMC Cancer·Grace M CallagyCarlos Caldas
Oct 9, 2008·BMC Cancer·Susanna L CookePaul A W Edwards
Apr 24, 2008·Breast Cancer Research : BCR·Yasmine NadlerYuval Kluger
Oct 22, 2008·Breast Cancer Research : BCR·Julie A VendrellPascale A Cohen
Apr 3, 2008·PloS One·Ningli ChengC Michael Knudson
Apr 11, 2013·PloS One·Miangela M LaclePaul J van Diest
Jun 12, 2013·PloS One·Stephanie N ShishidoThu A Nguyen
Apr 15, 2008·Future Oncology·François Bertucci, Anthony Goncalves
Jan 15, 2014·Chinese Journal of Cancer·Rui-An WangXiang-Hong Zhang
Feb 18, 2011·Journal of Cancer·Beatriz A WalterMaria J Merino
Dec 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Roger S-Y FooRichard N Kitsis
Jun 6, 2008·Expert Review of Proteomics·Steve Goodison, Virginia Urquidi
Jan 26, 2016·Molecular and Clinical Oncology·Rui-An WangDai-Ming Fan
Dec 11, 2013·Annals of Diagnostic Pathology·Basem Hasan ElesawyMohammad Arafa
Jan 22, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S Kalla SinghD De León
Sep 25, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S J DawsonC Caldas
May 6, 2008·The Breast : Official Journal of the European Society of Mastology·R Stuart-HarrisP Pharoah
Dec 7, 2007·Trends in Endocrinology and Metabolism : TEM·Jo K PerryPeter E Lobie
Jun 25, 2009·Cancer Science·Matthias ChristgenUlrich Lehmann
Dec 26, 2006·International Journal of Cancer. Journal International Du Cancer·Phil RollandLindy Durrant
Aug 21, 2008·International Journal of Cancer. Journal International Du Cancer·Matthias ChristgenUlrich Lehmann
Sep 11, 2012·Histopathology·Robert KornegoorPaul J van Diest

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.