PMID: 8938949Jan 1, 1996Paper

Bcl-2 oncoprotein expression is increased especially in the portion of small cell carcinoma within the combined type of small cell lung cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
M HigashiyamaR Tateishi

Abstract

Immunohistochemical analysis of Bcl-2 oncoprotein, one of the oncogenes associated with the regulation of programmed cell death, was performed on 12 surgically resected tumors of the combined type of small-cell lung cancer. Ten cases (83%) expressed Bcl-2 oncoprotein within the tumor tissues. Two of them showed its expression in both the small cell carcinoma and non-small cell carcinoma types, and 7 cases exhibited Bcl-2 expression only in the portion of the small cell carcinoma. Considering previous reports indicating a high prevalence of Bcl-2 oncoprotein expression in small cell lung cancer, it is suggested that Bcl-2 oncoprotein even in the combined type of lung cancer may play an important role in tumorigenesis and tumor development and ensuing histological alterations between small cell carcinoma and non-small cell carcinoma types.

Citations

Feb 19, 2010·Cancer Chemotherapy and Pharmacology·Paul K PaikLee M Krug
Apr 2, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Chuan WangJie Liu
Dec 23, 1998·Cancer Treatment Reviews·R DziadziuszkoJ Jassem
Jul 19, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Melinda M MortensonRichard J Bold
Aug 28, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xinyu YangMing Yang
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Angela M DaviesDavid R Gandara
Nov 12, 2003·Clinical Lung Cancer·Dean A Fennell

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