Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol

Brain Research
F Lezoualc'hC Behl

Abstract

The proto-oncogene bcl-2 can rescue cells from apoptosis and necrosis and its mechanism of action may involve antioxidant activity. The possible involvement of free radicals necrotic cell death induced by the neuroleptic drug haloperidol has led us to investigate the potential protective effect of Bcl-2 against haloperidol toxicity. We found that clonal mouse hippocampal cells stably transfected with the antioxidant Bcl-2 are protected against haloperidol toxicity. This data strongly supports the causative involvement of free radicals in haloperidol toxicity.

References

Jun 1, 1992·The American Journal of Psychiatry·M F EganR J Wyatt
Dec 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P MonaghanM F Greaves
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Nov 1, 1993·Trends in Neurosciences·C W Olanow
Feb 1, 1995·Journal of Neuroscience Research·D J KaneD E Bredesen
Jan 15, 1993·European Journal of Pharmacology·B J Vilner, W D Bowen
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M S ShearmanL L Iversen
Jan 28, 1993·Nature·M D JacobsonM C Raff
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L T ZhongD E Bredesen

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Citations

Feb 8, 2006·The Pharmacogenomics Journal·Z WeiX-M Li
Sep 18, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y ZhuJ Krieglstein
Oct 11, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Faizul AzamM M Alam
Dec 7, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Na Ri KimYoung Hoon Kim
Feb 1, 2014·The International Journal of Neuropsychopharmacology·Erin GardinerMurray J Cairns
Dec 27, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Charles E Dean
May 1, 2001·Current Protocols in Toxicology·A SamaliS Orrenius
Jan 30, 2008·Current Protocols in Cell Biology·B Zhivotovsky, S Orrenius

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