Abstract
The bcl-2 proto-oncogene functions as a cell death suppressor, and its expression prolongs cell survival by blocking apoptosis. Data available on the clinical relevance of bcl-2 protein expression in patients with non-small-cell lung cancer (NSCLC) are controversial. We analysed the role of bcl-2 protein expression on 6-year relapse-free survival in 229 patients with stage I-IIIa NSCLC (101 squamous cell carcinomas and 128 adenocarcinomas) subjected to surgery, with curative intent. Immunohistochemical analysis was performed on archival material by using a monoclonal antibody anti-bcl-2 (clone 124). Bcl-2 protein expression, which was detected in 22% of the cases, was significantly related to stage, histology and grading, and was an indicator of clinical outcome. The probability of relapse-free survival at 6 years was longer for patients with bcl-2-positive tumours (74%) than for those with bcl-2-negative tumours (57%) (P=0.02). This finding was mainly evident for the subgroups of patients with stage IIIa tumours (P=0.05), squamous cell carcinoma (P=0.03) or moderately/poorly differentiated tumours (P=0.02). However, multivariate analysis by Weibull's regression model indicated that bcl-2 protein expression was not an independe...Continue Reading
Citations
Aug 9, 2001·International Journal of Cancer. Journal International Du Cancer·S RorkeS C Tang
Sep 29, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K Junker
Oct 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·V RigauJ M Bréchot
Sep 27, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M TomitaT Onitsuka
Sep 16, 2000·Acta histochemica·V N NguyenV Mandys
Mar 9, 2000·Pancreas·T MeggiatoG Del Favero
May 13, 2010·BMC Cancer·Valsamo K AnagnostouKonstantinos N Syrigos
Sep 1, 2005·Annals of Surgical Oncology·Kazumasa TakenakaFumihiro Tanaka
Dec 20, 2011·Oncology Reports·Ya-Di WangJing Sun
Jul 19, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lars Henning SchmidtRainer Wiewrodt
Jun 11, 2003·Chest·Claudia PoleriMoisés Rosenberg
May 11, 2005·Biochemical and Biophysical Research Communications·Sudip SenNeeta Singh
Apr 25, 2015·The EPMA Journal·Godfrey GrechDominic M Desiderio
Mar 15, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eelco FokkemaHarry J M Groen
Apr 24, 2007·Journal of Korean Medical Science·Jinyoung YooHoon Kyo Kim
May 28, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Leos KrenJeffrey S Ross
Feb 24, 2001·Annals of the New York Academy of Sciences·B JosephB Zhivotovsky
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roy S Herbst, Stanley R Frankel
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil SinghalSteven M Albelda