Bcl-2 proteins: targets and tools for chemosensitisation of tumor cells

Current Medicinal Chemistry. Anti-cancer Agents
Ali BettaiebEric Solary

Abstract

Proteins of the Bcl-2 family share one or several Bcl-2 homology (BH) regions and behave as pro- or anti-apoptotic proteins. Prosurvival members such as Bcl-2 and Bcl-X(L) are supposed to preserve mitochondrial outer membrane integrity, thus preventing the release of soluble apoptogenic molecules. Pro-apoptotic members include BH3-only proteins that act as sensors of cellular damage and initiate the death process and Bax-like proteins that act downstream of BH3-only proteins to permeabilise the mitochondrial outer membrane. Whether BH3-only proteins directly activate Bax-like proteins or prevent prosurvival members of the family from inhibiting Bax-like proteins or both remains a matter of controversy. Expression of these proteins is altered in various human tumours and this abnormal expression may contribute to oncogenesis and tumour cell resistance to anticancer drug-induced cell death. Based on these observations, prosurvival proteins are attractive intracellular targets for inducing tumour cell death or sensitising tumour cells to death induced by chemotherapeutic drugs. The use of 18-mer antisense oligonucleotides (G3139 or Genasense) targeting the first six codons of bcl-2 mRNA is currently developed in clinics with phase...Continue Reading

Citations

May 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·R X-D SongR J Santen
Aug 31, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hsi-Hsien HsuChih-Yang Huang
Mar 17, 2007·Medical Hypotheses·George E Parris
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Takamitsu HaraTomio Inoue
Sep 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Yusran Abdul AzizNoorjahan Banu Alitheen
Aug 6, 2004·The Journal of Biological Chemistry·Jung-Hee LeeJeong-Hwa Lee
Apr 21, 2005·Pancreas·Jyotika SharmaJai Dev Wig
Dec 3, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M M MitaA W Tolcher
Jun 28, 2016·Oncology Letters·Raffaella GiuffridaConcetta Conticello
Mar 10, 2020·Oxidative Medicine and Cellular Longevity·Zhihao ZhangYoutan Liu

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