Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway

Experimental Cell Research
J L HerrmannT J McDonnell

Abstract

A role has been delineated for both bcl-2 and NF-kappa B in mediating an adaptive survival response to the TNF-alpha signaling pathway for apoptosis. Additionally, we and others have demonstrated a role for bcl-2 upregulation during progression of prostate cancer and acquisition of androgen-independent growth (T. J. McDonnell et al., 1992, Cancer Res. 52, 6940-6944). Therefore, the relationship between bcl-2 and NF-kappa B in regulating TNF-alpha-induced apoptosis was investigated in prostate carcinoma cells. Enforced overexpression of bcl-2 protein in prostatic carcinoma cells impaired TNF-alpha-mediated cytotoxicity. Expression of bcl-2 did not impose a block to, or potentiate, TNF-alpha signaling of I kappa B alpha degradation, nuclear import of the RelA p65, or NF-kappa B-dependent transactivation. Expression of two dominant-negative I kappa B alpha mutant proteins significantly enhanced TNF-alpha-induced apoptosis in control cells but not in cells expressing high levels of bcl-2 protein. Similarly, PDTC, a strong antioxidant that interferes with activation of NF-kappa B in these prostate carcinoma cells, also potentiated TNF-alpha-stimulated apoptosis signaling through a bcl-2-regulated mechanism. These findings indicate t...Continue Reading

Citations

Jul 21, 2007·Nutrition and Cancer·Merrill J ChristensenBrett R Barzee
Jun 29, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A BeresfordN J Donato
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·H Y Zhang, S H Phan
Sep 2, 2010·PloS One·Regina Berretta, Pablo Moscato
Jan 20, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Sagar DhamneNina Tatevian
Sep 26, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Abhilash SamykuttyMunirathinam Gnanasekar
Oct 27, 2005·Journal of Biochemistry and Molecular Biology·Shishir Shishodia, Bharat B Aggarwal
Feb 19, 2015·Archives of Toxicology·Feng LiGautam Sethi
Oct 10, 2009·Integrative Cancer Therapies·Gazala N KhanSofia D Merajver
Dec 23, 2003·Journal of Cellular Biochemistry·Junghan Suh, Arnold B Rabson
Dec 22, 1999·Oncogene·B Rayet, C Gélinas
Jul 12, 2002·The Prostate·Junghan SuhArnold B Rabson
Feb 18, 2004·Journal of Korean Medical Science·Jaetaek KimSoon-Hyun Shinn
Aug 28, 2004·Cancer Gene Therapy·Bahri KaracayDaniel J Bonthius
May 20, 2014·Molecular Diagnosis & Therapy·Anubhav JainPrakash S Bisen
Aug 29, 2002·The Journal of Biological Chemistry·Xin BianValerie P Castle
Jun 7, 2000·The Journal of Biological Chemistry·J Doostzadeh-CizeronD W Goodrich
Feb 8, 2008·The Biochemical Journal·Georgina L Hold, Emad M El-Omar
Apr 7, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·A S AbdulamirFatimah Abubakar
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chanatip OoppachaiSupachai Yodkeeree
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey S RossBradley Stringer

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