bcl-2/Adenovirus E1B 19-kd interacting protein 3 (BNIP3) regulates hypoxia-induced neural precursor cell death.

Journal of Neuropathology and Experimental Neurology
Ken C WallsKevin A Roth

Abstract

Perinatal hypoxia-ischemia may result in long-term neurological deficits. In addition to producing neuron death, HI causes death of neural precursor cells (NPCs) in the developing brain. To characterize the molecular pathways that regulate hypoxia-induced death of NPCs, we treated a mouse neural stem cell line (C17.2 cells) and fibroblastic growth factor II-expanded primary NPCs derived from wild-type or gene-disrupted mice, with oxygen glucose deprivation or the hypoxia mimetics desferrioxamine or cobalt chloride. Neural precursor cells undergoing hypoxia exhibited time- and concentration-dependent caspase-3 activation and cell death, which was significantly reduced by treatment with a broad caspase inhibitor or protein synthesis inhibition. Bax/Bak-deficient NPCs were protected from desferrioxamine-induced death and exhibited minimal caspase-3 activation. Oxygen glucose deprivation or hypoxia-mimetic exposure also resulted in increased hypoxia-inducible factor alpha and bcl-2/adenovirus E1B 19-kd interacting protein 3 (BNIP3) expression. BNIP3 shRNA treatment failed to affect hypoxia-induced caspase-3 activation but inhibited cell death and nuclear translocation of apoptosis-inducing factor, indicating that BNIP3 is an import...Continue Reading

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Citations

Jan 10, 2014·The Journal of Investigative Dermatology·Mariko MoriyamaTakao Hayakawa
May 23, 2013·Journal of Neurochemistry·Chengren LiJiming Kong
Jan 11, 2013·Journal of Cellular and Molecular Medicine·Mayur V JainMarek Łos
Sep 8, 2010·Biochimica Et Biophysica Acta·Emily F Mason, Jeffrey C Rathmell
Mar 31, 2017·Acta Oncologica·Sourabh Soni, Yogendra S Padwad
Jun 19, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yongzhen XueHui Li
Mar 7, 2019·American Journal of Physiology. Cell Physiology·Qingyi MaWilliam J Pearce
Sep 2, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Z MaZ Yu
Jul 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hiromitsu KunimiToshihide Kurihara

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