BCL-6 and other genomic alterations in non-Hodgkin's lymphoma (NHL)

British Journal of Cancer
M ButlerD N Carney

Abstract

This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearranged in 42% of follicle centre lymphomas (FCL) and in 15% of diffuse large B-cell (DLBC) lymphomas. In this study, 80% of the c-MYC rearrangements were detected in aggressive diffuse lymphoma subsets but, interestingly, 9% of FCL showed involvement of t(8q24) translocation. In our study, rearrangements of the BCL-6 gene at band 3q27 were found in 31% of DLBC lymphomas. Interestingly, 50% of the BCL-6 rearrangement positive lymphoma cases had coexisting gene rearrangements involving all of the aforementioned gene loci. The molecular dissection of these genes will improve our understanding of the genesis of the diverse clinicopathological subtypes.

Citations

May 16, 2000·Cancer Investigation·B H Ye
May 17, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Yin XuSteven H Kroft
Jan 21, 2010·Cancer Causes & Control : CCC·Pia FernbergKarin Ekström Smedby
Dec 6, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·B E KingS H Swerdlow
Mar 17, 2007·Cancer Research·Michelle L DuquetteNancy Maizels

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