BCL6 expression correlates with the t(1;19) translocation in B-lymphoblastic leukemia

American Journal of Clinical Pathology
Anne M DeucherJoan E Etzell

Abstract

Study to date suggests that BCL6 protein expression in B-cell neoplasia predominates in germinal center-derived tumors, but less is known regarding its expression in B-lymphoblastic leukemia. Therefore, we designed a comprehensive study of BCL6 expression in B-lymphoblastic leukemia. BCL6, LMO, and HGAL protein expression in B-lymphoblastic leukemia was investigated using immunohistochemical staining of paraffin-embedded bone marrow specimens. Cryptic TCF3(E2A)-PBX1 rearrangements were investigated using interphase fluorescence in situ hybridization. Six (12%) of 52 B-lymphoblastic leukemias demonstrated BCL6 protein expression, with B-cell lymphoblastic leukemias containing a t(1;19) translocation demonstrating the strongest staining (three of three). Additional t(1;19) cases beyond the screening study showed similar results. Public microarray expression database mining showed that BCL6 messenger RNA expression levels in B-lymphoblastic leukemia correlated with the protein expression findings. Finally, other markers of B-cell development correlated with BCL6 expression in t(1;19) B-lymphoblastic leukemia cases, with LMO2 and HGAL proteins expressed in six (67%) of nine and eight (89%) of nine cases, respectively. BCL6 expressi...Continue Reading

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Citations

Jun 26, 2015·Open Biology·Jennifer Chambers, Terence H Rabbitts
Nov 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weiwei ShanXin Lu
Sep 22, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Renato BassanSabina Chiaretti
Jun 9, 2018·The EMBO Journal·Idoia García-RamírezIsidro Sánchez-García

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