PMID: 9159141May 27, 1997Paper

BCL8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large-cell lymphoma

Proceedings of the National Academy of Sciences of the United States of America
V G DyominR S Chaganti

Abstract

Translocations affecting the chromosomal region 15q11-13 and various other partners are recurrent in diffuse large-cell lymphomas (DLCL). To identify the putative gene, here named BCL8, involved in these translocations we have cloned the breakpoint region from a DLCL patient with t(14;15)(q32;q11-13) and the corresponding germ-line region from chromosome 15. The genomic locus on chromosome 15 is clonally rearranged in about 4% of DLCL in agreement with the frequency of 15q11-13 translocations. A probe derived from the BCL8 locus on chromosome 15 detected a transcript in human testis and prostate, whereas no expression was found in spleen, thymus, and blood leukocytes. Analysis of the BCL8 cDNA clones isolated from human testis cDNA library showed that the BCL8 gene generates a major transcript of 2.6 kb and a less prominent 4.5-kb species due to differential polyadenylylation. By reverse transcription-PCR analysis of RNA extracted from frozen DLCL samples and lymphoma cell lines, BCL8 expression was detected in all patients carrying 15q11-13 abnormalities and in a fraction of randomly selected DLCL patients. These results suggest that the BCL8 gene is not normally expressed in lymphoid tissues, but its expression can be activat...Continue Reading

References

Mar 1, 1992·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M Ladanyi, S Wang
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·R Dalla-FaveraS Chaganti
Apr 1, 1995·Human Molecular Genetics
Jun 1, 1994·Human Molecular Genetics·I M TomlinsonG Winter
Nov 10, 1994·Nature·T H Rabbitts
Jul 14, 1994·The New England Journal of Medicine·K OffitA Rosenbaum

❮ Previous
Next ❯

Citations

May 25, 1999·Genes, Chromosomes & Cancer·J C CigudosaR S Chaganti
Mar 10, 2001·The Journal of Molecular Diagnostics : JMD·D A Arber
Oct 3, 1999·Current Opinion in Oncology·A Sarris, R Ford
May 29, 1998·Immunological Reviews·U KleinR Küppers
Nov 17, 2004·Cytogenetic and Genome Research·D P LockeE E Eichler
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T GoossensR Küppers
Jul 16, 2005·Hematology·Fabrice Jardin, Surinder S Sahota
Jun 19, 2008·Cancer Genetics and Cytogenetics·Atsushi FujiedaNaoyuki Katayama
Sep 5, 1998·Cancer Treatment Reviews·D W HammondM H Goyns
Dec 24, 2005·Pathology·Alberto Catalano, Harry Iland
Feb 5, 2013·Critical Reviews in Oncology/hematology·Maurizio MartelliStefano A Pileri
Jun 30, 2016·Genes, Chromosomes & Cancer·Claudia OttoUNKNOWN “Molecular Mechanisms in Malignant Lymphomas” Network Project
Dec 21, 2004·World Journal of Gastroenterology : WJG·Da-Liu MinDa-Ren Shi
Jul 1, 2009·Molecular and Cellular Biology·Fang WeiMichael L Atchison
Jan 24, 2008·Molecular and Cellular Biology·Lourdes M MendezB Hilda Ye
Dec 3, 1999·Archives of Pathology & Laboratory Medicine·L J Medeiros, J Carr

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.