BCN Checkpoint: same-day confirmation of reactive HIV rapid test with Point Of Care HIV-RNA accelerates linkage to care and reduces anxiety

HIV Medicine
M MeulbroekJ Saz

Abstract

The introduction in 2006 of the rapid HIV test by BCN Checkpoint in a non-clinical setting has been a successful step forwards in the uptake of testing. Nevertheless, HIV serostatus should be reported as HIV positive only when a reactive result has been tested again using a different assay (WHO guidelines 2015). The standard confirmation test has been the Western Blot (WB) test. However confirmation results take around 7 days to come back. This study explores the possibility of Point of Care PCR testing for a same-day confirmation. Between March 2015 and September 2016 a POC PCR test (Xpert® HIV-1 Qual) was performed in parallel to the Western Blot test after a reactive HIV rapid test (Alere Determine™ HIV-1/2 Ag/Ab Combo and Alere™ HIV Combo). HIV confirmed positive cases received emotional support by peers, were informed and prepared for treatment initiation and rapidly linked to HIV clinic. During the study period 11 455 tests were performed to 7163 clients. A total of 249 reactive rapid HIV tests were found. For analysis a total of 33 cases were excluded due to the lack of PCR and/or WB test. Results of comparison of the 216 cases showed 194 concordant positive confirmations and 14 concordant negative results. In three case...Continue Reading

Associated Clinical Trials

Citations

May 17, 2019·Clinical Microbiology Reviews·Paul K DrainNigel Garrett
Jul 24, 2020·International Journal of STD & AIDS·Gary WhitlockUNKNOWN Dean Street Collaborative Group
Jul 12, 2020·Journal of Medical Virology·Lifeng LiuTong Zhang
May 6, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maartje DijkstraUNKNOWN HIV Transmission Elimination Amsterdam (H-TEAM) Initiative

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