PMID: 7542908Jun 1, 1995Paper

BCR/ABL fusion located on chromosome 9 in chronic myeloid leukemia with a masked Ph chromosome

Genes, Chromosomes & Cancer
A N MohamedF H Sarkar

Abstract

A reciprocal translocation, t(10;22)(q22;q11), resulting in a masked Ph chromosome was identified in a patient diagnosed with chronic myeloid leukemia (CML). Both homologs of chromosome 9 were of the normal pattern. Two signals for the ABL probe, both of them hybridized to chromosome 9, were demonstrated via fluorescence in situ hybridization (FISH). Furthermore, cohybridization with two differently labeled BCR/ABL translocation DNA probes indicated a BCR/ABL fusion apparently located on 9q34. Molecular studies revealed a rearrangement of the BCR region and expression of a chimeric BCR/ABL mRNA of CML configuration. These findings indicate that the BCR/ABL fusion resulted from an unusual relocation of the BCR gene from its normal position on 22q11 to 9q34 adjacent to the ABL gene.

References

Jan 1, 1990·Cytogenetics and Cell Genetics·E P ArnoldusA K Raap
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Citations

Nov 11, 1998·Cancer Genetics and Cytogenetics·K S Reddy, B Grove
Dec 2, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Manisha M BrahmbhattPrabhudas S Patel
Apr 25, 2006·Cancer Genetics and Cytogenetics·Biljana Todorić-ZivanovićMariano Rocchi
Nov 13, 2007·Hematology/oncology Clinics of North America·Giovanni Tonon
Sep 27, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B C FigueiredoR Sandrini

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