BCRP/ABCG2 in the placenta: expression, function and regulation.

Pharmaceutical Research
Qingcheng Mao

Abstract

Knowledge concerning transport of maternally administered drugs across the placental barrier is essential for determining potential toxicity of drugs to the fetus and the value of drug therapy during pregnancy. An important determinant for fetal drug exposure is the expression of efflux transporters in the placenta. Among human tissues, the ATP-binding cassette efflux transporter BCRP (gene symbol ABCG2) is most abundantly expressed in the apical membrane of placental syncytiotrophoblasts. Although the precise physiological role of BCRP in the placenta is still unclear, existing data strongly suggest that BCRP plays an important role in protecting the fetus against the potential toxicity of drugs, xenobiotics, and metabolites by expelling them across the placental barrier. In this review, we summarize the current knowledge with respect to the expression, function, and polymorphisms of BCRP, as well as transcriptional and posttranscriptional regulation of the transporter in the placenta. Finally, clinical significance of BCRP in the placenta for drug therapy in pregnant women is discussed.

References

Nov 1, 1984·American Journal of Obstetrics and Gynecology·F S Khan-Dawood, M Y Dawood
Oct 24, 1998·Journal of Reproductive Immunology·D W MorrishH Li
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Mar 23, 1999·Pflügers Archiv : European journal of physiology·P E GolsteinR Beauwens
Feb 24, 2000·Biology of Reproduction·C CudevilleF Ferré
Oct 19, 2000·Journal of the National Cancer Institute·J W JonkerA H Schinkel
Oct 19, 2000·The New England Journal of Medicine·O LangerO Gonzales
Jun 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M F KruijtzerJ H M Schellens
Aug 6, 2002·Journal of Mammary Gland Biology and Neoplasia·Margaret C NevilleIsabel Forsyth
Nov 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Johan W JonkerAlfred H Schinkel
Nov 15, 2002·Cancer Biology & Therapy·W Stratford May, Peter P Ruvolo
Mar 19, 2003·Cancer Biology & Therapy·Yasumasa HonjoSusan E Bates
Apr 25, 2003·American Journal of Obstetrics and Gynecology·Douglas D GloverTimothy S Tracy
Aug 16, 2003·Molecular Pharmacology·Yasuo ImaiYoshikazu Sugimoto
Feb 18, 2004·Current Drug Metabolism·Jashvant D UnadkatShashi Vijay
Feb 26, 2004·American Journal of Obstetrics and Gynecology·Douglas D GloverTimothy S Tracy
Mar 10, 2004·The Journal of Pharmacology and Experimental Therapeutics·Anshul GuptaQingcheng Mao
Mar 27, 2004·The Journal of Biological Chemistry·Partha KrishnamurthyJohn D Schuetz
Apr 16, 2004·The Journal of Steroid Biochemistry and Molecular Biology·T FlötottoB Hanstein
Apr 23, 2004·Molecular Pharmacology·Shuzhong ZhangMarilyn E Morris
Jun 2, 2004·Clinical Pharmacokinetics·Michael R SymeJeffrey A Keelan
Sep 3, 2004·American Journal of Obstetrics and Gynecology·Susan E AndradeRichard Platt
Oct 12, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Daisuke KobayashiYuichi Sugiyama
Nov 30, 2004·Biochemical and Biophysical Research Communications·Yuji TanakaCurtis D Klaassen
Jan 11, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Dhanashri KolwankarTimothy S Tracy
Apr 12, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Henriette E Meyer zu SchwabedissenHeyo K Kroemer
May 27, 2005·Biology of Reproduction·Grazyna M KalabisStephen G Matthews
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anita A MathiasJashvant D Unadkat
Sep 9, 2005·The AAPS Journal·Qingcheng Mao, Jashvant D Unadkat
Oct 26, 2005·Bioscience, Biotechnology, and Biochemistry·Satoru YasudaKen Iseki

❮ Previous
Next ❯

Citations

Nov 20, 2009·Archives of Gynecology and Obstetrics·Valeria FeinshteinZvi Ben-Zvi
Dec 5, 2013·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Elgida R VolpicelliGeorge F Murphy
Mar 14, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Peng Duan, Guofeng You
Feb 6, 2013·Chemistry Central Journal·Yugyung LeeChi H Lee
Feb 21, 2009·World Journal of Gastroenterology : WJG·Rocio I R MaciasMaria A Serrano
Sep 24, 2013·PeerJ·Valeria FeinshteinGershon Holcberg
Dec 3, 2014·Biochemical Pharmacology·Diana L ShusterQingcheng Mao
Jul 14, 2011·Stem Cell Reviews and Reports·Qiang BaiJohn De Vos
Sep 30, 2009·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Aug 27, 2010·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenElina Sieppi
Dec 11, 2008·Journal of Pharmaceutical Sciences·Abhishek Gulati, Phillip M Gerk
May 8, 2009·Journal of Pharmaceutical Sciences·Yi ZhangQingcheng Mao
Apr 18, 2013·Journal of Pharmaceutical Sciences·Kenji OdaEmi Nakashima
Aug 11, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Ozan Yüksel TektaşFriedrich Paulsen
Jan 31, 2012·Reproductive Toxicology·Magali E RidanoGraciela M Panzetta-Dutari
May 15, 2010·Toxicology Letters·Vesa KarttunenKirsi Vähäkangas
Oct 21, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D BeghinS Gil
Jan 3, 2009·Advanced Drug Delivery Reviews·Maria L H VlamingAlfred H Schinkel
Jan 7, 2009·Advanced Drug Delivery Reviews·Christopher A McDevittRichard Callaghan
Nov 18, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D BeghinS Gil
Oct 1, 2009·British Journal of Pharmacology·Kirsi Vähäkangas, Päivi Myllynen
May 11, 2011·The FEBS Journal·Owen M WoodwardMichael Köttgen
Nov 19, 2015·Journal of Applied Genetics·Aleksandra Salagacka-KubiakEwa Balcerczak
Jun 20, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sabrina Nickel, Anne Mahringer
Apr 5, 2014·Thérapie·Danièle Evain-BrionSophie Gil
Nov 4, 2016·Pharmaceutical Research·Anand A JoshiPhillip M Gerk
Feb 9, 2016·Scientific Reports·Jeyan S KumarMichael M Gottesman
Apr 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariline GameiroFernando Remião
May 24, 2011·Reproductive Sciences·Sophie PetropoulosStephen G Matthews
Nov 30, 2018·Drug Metabolism Letters·Lyrialle W HanQingcheng Mao
Aug 12, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Lukas CervenyFrantisek Staud
Apr 11, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Qingcheng MaoJoanne Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.