BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4

Molecular Biology of the Cell
Baojin DingDaniel L Kilpatrick

Abstract

We show that BDNF regulates the timing of neurodevelopment via a novel mechanism of extranuclear sequestration of NFATc4 in Golgi. This leads to accelerated derepression of an NFI temporal occupancy gene program in cerebellar granule cells that includes Bdnf itself, revealing an autoregulatory loop within the program driven by BDNF and NFATc4.

References

Aug 1, 1993·Journal of Neuroscience Research·Y MasanaM Tohyama
Jun 13, 1998·Brain Research. Developmental Brain Research·X LinR F Bulleit
Sep 15, 1998·Trends in Neurosciences·D Goldowitz, K Hamre
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y ChenW H Lee
May 1, 2001·Thyroid : Official Journal of the American Thyroid Association·N KoibuchiW W Chin
Apr 28, 2004·Trends in Neurosciences·Alexey SemyanovR Angus Silver
Oct 7, 2004·The Journal of Biological Chemistry·Wei WangDaniel L Kilpatrick
Nov 13, 2004·The Journal of Biological Chemistry·Alessandra B BeneditoAzad Bonni
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Masaaki SatoShigetada Nakanishi
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoojin ChoiRosalind A Segal
Jan 24, 2006·Biochemical and Biophysical Research Communications·Masaaki SatoShigetada Nakanishi
Jun 24, 2006·The Journal of Physiology·Shigetada Nakanishi, Makoto Okazawa
Dec 7, 2006·Journal of Neuroscience Research·Tamara AidTõnis Timmusk
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei WangDaniel L Kilpatrick
Sep 25, 2007·Brain Research·Christian BarbatoCarlo Cogoni
Apr 3, 2008·Molecular and Cellular Neurosciences·Timothy K SpencerMarie T Filbin
Oct 7, 2008·Biochemical and Biophysical Research Communications·Revati J TatakeRoger J Snow
Jul 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manabu KokuboAnthony R Means
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aruna VashishtaMichal Hetman
Dec 31, 2010·Cellular and Molecular Neurobiology·Wei WangDaniel L Kilpatrick
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Haruka AbeShigetada Nakanishi
May 1, 2012·Trends in Neurosciences·Rhiannon M MeredithIoannis Kramvis
May 2, 2012·The Cerebellum·Daniel L KilpatrickE David Litwack
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Haruka AbeShigetada Nakanishi
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Baojin DingDaniel L Kilpatrick
May 18, 2013·Methods in Molecular Biology·Tharakeswari Selvakumar, Daniel L Kilpatrick
May 18, 2013·Methods in Molecular Biology·Baojin Ding, Daniel L Kilpatrick
Jan 16, 2014·The Journal of Biological Chemistry·Hong ZhuChi-Wing Chow
Aug 8, 2014·Neuron·Samuel S-H WangAleksandra Badura
Nov 12, 2014·Annual Review of Physiology·Xintong DongHannes E Bülow
Jan 28, 2015·Trends in Genetics : TIG·Mikihito ShibataNenad Sestan
May 9, 2015·Frontiers in Behavioral Neuroscience·Alberto J López, Marcelo A Wood
Aug 21, 2015·Nature Reviews. Neuroscience·Thomas Bourgeron

❮ Previous
Next ❯

Citations

Jan 30, 2021·Neural Regeneration Research·Baojin Ding

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM130

Methods Mentioned

BETA
ChIP
immunoprecipitation
confocal microscopy
PCR
fluorescence microscopy

Software Mentioned

ImageJ
Image Pro Plus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.