BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

Trends in Neurosciences
Mark P MattsonBronwen Martin

Abstract

Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, Alzheimer's disease and Huntington's disease. Enhancement of BDNF signaling may be a key mechanism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve brain function during aging. Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging.

Associated Clinical Trials

References

Apr 1, 1987·Journal of the American Geriatrics Society·D G MorganC E Finch
Jun 1, 1995·The European Journal of Neuroscience·T E AllsoppA M Davies
Sep 24, 1993·Annals of the New York Academy of Sciences·G Richter-Levin, M Segal
Mar 28, 1998·The European Journal of Neuroscience·S LinnarssonP Ernfors
Dec 1, 1998·European Journal of Pharmacology·I SemkovaJ Krieglstein
Oct 12, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Russo-NeustadtC W Cotman
Nov 2, 1999·Biochemical and Biophysical Research Communications·S J AllenD Dawbarn
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E LarssonO Lindvall
May 23, 2000·Annals of Medicine·M C BuhotL Segu
May 29, 2000·Brain Research·I FerrerT Ribalta
Feb 20, 2002·JAMA : the Journal of the American Medical Association·Robert S WilsonDavid A Bennett
Jun 28, 2002·Trends in Neurosciences·Carl W Cotman, Nicole C Berchtold
Aug 2, 2002·Neuroreport·Mitchell K P LaiChristopher P L-H Chen
Aug 8, 2002·Archives of Neurology·Jose A LuchsingerRichard Mayeux
Oct 18, 2002·Nature·Robert BlumArthur Konnerth
Feb 1, 2003·Experimental Gerontology·P Arivazhagan, C Panneerselvam
Feb 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wenzhen DuanMark P Mattson
Apr 12, 2003·Trends in Neurosciences·Patrik Ernfors, Clive R Bramham
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·R Michael AnsonMark P Mattson
May 22, 2003·Pharmacology, Biochemistry, and Behavior·A S IvyA A Russo-Neustadt
Jun 5, 2003·International Journal of Psychiatry in Medicine·Stefanie A HorsfieldStephen I Deutsch
Jul 10, 2003·Current Opinion in Neurobiology·Peter Vanhoutte, Hilmar Bading
Sep 11, 2003·Annals of Internal Medicine·Mark P Mattson
Oct 14, 2003·Experimental Neurology·Jianmin ZhangFred J Roisen

❮ Previous
Next ❯

Citations

Jan 30, 2014·Translational Psychiatry·V R VennaL D McCullough
Oct 29, 2013·Sports Medicine·Joshua DenhamFadi J Charchar
Jan 10, 2014·Cellular and Molecular Neurobiology·Qing-Qiu MaoSiu-Po Ip
Apr 24, 2014·Brain : a Journal of Neurology·Veronica FrancardoM Angela Cenci
Oct 20, 2010·ASN Neuro·Aiwu ChengMark P Mattson
Dec 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Caleb E Finch
Dec 12, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaofang LanGuangqin Li
Dec 15, 2010·International Journal of Alzheimer's Disease·Wayne ChadwickStuart Maudsley
Aug 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Moseon LeeJaehee Kim
May 16, 2007·Neural Plasticity·Allan V Kalueff
Apr 13, 2011·Journal of Cell Communication and Signaling·Edward J Calabrese, Mark P Mattson
Feb 8, 2006·Postgraduate Medical Journal·R Peters
Mar 23, 2006·Nature Reviews. Neuroscience·Mark P Mattson, Tim Magnus
Dec 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan P GodboutRodney W Johnson
Feb 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pedro BekinschteinJorge H Medina
Apr 12, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicholas P WhitneyJialin C Zheng
Nov 28, 2008·Annual Review of Psychology·Denise C Park, Patricia Reuter-Lorenz
Sep 19, 2009·Neuromolecular Medicine·Emmette R HutchisonMark P Mattson
Jan 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonio TerraccianoPaul T Costa
Sep 21, 2010·Antioxidants & Redox Signaling·Sarah J Texel, Mark P Mattson
May 3, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Kirk I EricksonKathryn A Roecklein
Jul 1, 2011·BMC Neuroscience·Sung-Soo ParkStuart Maudsley
Jan 30, 2013·International Journal of Molecular Sciences·Mohammad Shamsul OlaAbdullah S Alhomida
Dec 8, 2006·Diabetologia·K S KrabbeB K Pedersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.