BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal

Nature Neuroscience
Lu PuMu-Ming Poo

Abstract

The neural mechanism underlying the relapse to drug use after drug withdrawal is largely unknown. We found that after withdrawal from repeated cocaine exposure, excitatory synapses onto dopamine neurons in the ventral tegmental area (VTA) of the rat midbrain became highly susceptible to potentiation by weak presynaptic stimuli, an effect requiring endogenous brain-derived neurotrophic factor-tyrosine kinase B (BDNF-TrkB) signaling. The elevated BDNF expression in the VTA after cocaine withdrawal may prime these synapses for potentiation by cue-associated activity, triggering drug craving and relapse.

References

Aug 23, 1990·Nature·J M Bekkers, C F Stevens
Apr 16, 1999·Nature Neuroscience·L M BoulangerM M Poo
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
Mar 20, 2001·Nature Reviews. Neuroscience·M M Poo
Oct 5, 2001·Nature Reviews. Neuroscience·S E Hyman, R C Malenka
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shigeo WatanabeDaniel Johnston
Oct 21, 2003·Nature Neuroscience·Colleen A McClung, Eric J Nestler
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lin LuYavin Shaham

❮ Previous
Next ❯

Citations

Oct 21, 2011·Molecular Neurobiology·Joshua Cordeira, Maribel Rios
Oct 2, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Margarida Corominas-RosoMiguel Casas
Feb 22, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Frederick A SchroederSchahram Akbarian
Dec 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maribel Rios
May 22, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Junshi WangElla M Nikulina
Aug 15, 2013·Nature Reviews. Neuroscience·Scott J Russo, Eric J Nestler
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter W Kalivas, Charles O'Brien
Jan 25, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marc N PotenzaJoel Gelernter
May 13, 2009·Pharmacopsychiatry·D M DietzS J Russo
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jane Stewart
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hui LuMu-Ming Poo
Feb 16, 2008·Annual Review of Neuroscience·Natalia Caporale, Yang Dan
Apr 21, 2011·The Journal of Clinical Investigation·Maxime CazorlaDidier Rognan
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Klaus A MiczekHerbert E Covington
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming GaoJie Wu
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kee-Chan AhnHitoshi Morikawa
Feb 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua W CordeiraMaribel Rios
May 27, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kwang Ho ChoiDavid W Self
Jun 19, 2012·Progress in Neurobiology·Fabien BoulleDaniel L A van den Hove
May 31, 2011·Progress in Neurobiology·Michelle R Lyons, Anne E West
Feb 1, 2011·Neuropharmacology·Manuel Mameli, Christian Lüscher
Mar 9, 2010·Trends in Neurosciences·Scott J RussoEric J Nestler
Oct 24, 2009·Neuroscience Letters·Soo-Young BhangJoon-Ho Ahn
Feb 19, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fabio FumagalliMarco Andrea Riva
Jul 24, 2008·Neuropharmacology·Scott J RussoEric J Nestler
Apr 9, 2008·Pharmacology & Therapeutics·Margaret I Davis
Mar 17, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Shiguo LiuXu Ma
Mar 12, 2016·Behavioural Brain Research·Elizabeth E Manning, Maarten van den Buuse
Nov 7, 2006·Trends in Neurosciences·Lin LuYavin Shaham
Oct 11, 2015·The International Journal of Neuropsychopharmacology·Elizabeth E ManningMaarten van den Buuse
Mar 18, 2008·British Journal of Pharmacology·M J ThomasY Shaham
Apr 11, 2007·Journal of Neurochemistry·B R HooverN R Zahniser
Nov 16, 2007·The European Journal of Neuroscience·Fabio FumagalliMarco Andrea Riva
Jul 27, 2007·The European Journal of Neuroscience·William J BerglindJacqueline F McGinty
Dec 17, 2010·CNS Neuroscience & Therapeutics·Takahide Shuto, Akinori Nishi
Jun 23, 2011·The European Journal of Neuroscience·Xuan Li, Marina E Wolf
Apr 23, 2014·CNS Neuroscience & Therapeutics·Lu-Yao MaJie Wu
May 26, 2007·Brain Research·Daniel H WolfDavid S Russell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
F Scott HallGeorge R Uhl
The European Journal of Neuroscience
William J BerglindJacqueline F McGinty
© 2022 Meta ULC. All rights reserved