BDNF genotype and tDCS interaction in aphasia treatment

Brain Stimulation
Julius FridrikssonLeonardo Bonilha

Abstract

Several studies, including a randomized controlled trial by our group, support applying anodal tDCS (A-tDCS) to the left hemisphere during behavioral aphasia treatment to improve outcomes. A clear mechanism explaining A-tDCS's efficacy has not been established, but modulation of neuroplasticity may be involved. The brain-derived neurotrophic factor (BDNF) gene influences neuroplasticity and may modulate the effects of tDCS. Utilizing data from our recently completed trial, we conducted a planned test of whether aphasia treatment outcome is influenced by interaction between A-tDCS and a single-nucleotide polymorphism of the BDNF gene, rs6265. Seventy-four individuals with chronic stroke-induced aphasia completed 15 language therapy sessions and were randomized to receive 1 mA A-tDCS or sham tDCS (S-tDCS) to the intact left temporoparietal region for the first 20 min of each session. BDNF genotype was available for 67 participants: 37 participants had the typical val/val genotype. The remaining 30 participants had atypical BDNF genotype (Met allele carriers). The primary outcome factor was improvement in object naming at 1 week after treatment completion. Maintenance of treatment effects was evaluated at 4 and 24 weeks. An intera...Continue Reading

Citations

Sep 13, 2019·Stroke; a Journal of Cerebral Circulation·Shauna Berube, Argye E Hillis
Nov 23, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Sigfus KristinssonJulius Fridriksson
May 5, 2020·Expert Review of Neurotherapeutics·Argye E Hillis
Nov 2, 2019·The American Journal of Psychiatry·Mark S George
Jul 31, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nikhil MathPankaj Sharma
Nov 25, 2020·Expert Review of Neurotherapeutics·Shannon M Sheppard, Rajani Sebastian
Dec 22, 2020·Current Physical Medicine and Rehabilitation Reports·Bonnie L Breining, Rajani Sebastian
Jan 7, 2021·Brain Sciences·Chiara PicanoPaola Marangolo
Mar 5, 2021·Seminars in Neurology·David J Lin, Steven C Cramer
Apr 17, 2021·Neuroscience and Biobehavioral Reviews·Sophie Arheix-ParrasBertrand Glize
Jun 10, 2021·Journal of Stroke·Julius Fridriksson, Argye Elizabeth Hillis
Jun 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Andrew T DeMarcoPeter E Turkeltaub
Jul 13, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Shreya ParchureRoy H Hamilton
Aug 10, 2021·Behavioural Neurology·Nathan T LeeKai Ling Chin
Dec 23, 2021·Neurorehabilitation and Neural Repair·Steven C CramerCarolee J Winstein

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Methods Mentioned

BETA
blood draw
genotyping
PCR

Software Mentioned

SAS

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