BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation

The Journal of Cell Biology
Gianluca FulgenziLino Tessarollo

Abstract

Brain-derived neurotrophic factor (BDNF) is critical for mammalian development and plasticity of neuronal circuitries affecting memory, mood, anxiety, pain sensitivity, and energy homeostasis. Here we report a novel unexpected role of BDNF in regulating the cardiac contraction force independent of the nervous system innervation. This function is mediated by the truncated TrkB.T1 receptor expressed in cardiomyocytes. Loss of TrkB.T1 in these cells impairs calcium signaling and causes cardiomyopathy. TrkB.T1 is activated by BDNF produced by cardiomyocytes, suggesting an autocrine/paracrine loop. These findings unveil a novel signaling mechanism in the heart that is activated by BDNF and provide evidence for a global role of this neurotrophin in the homeostasis of the organism by signaling through different TrkB receptor isoforms.

References

Mar 1, 1995·The Biochemical Journal·M D BootmanR Casteels
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·U MendeE J Neer
Jan 19, 2002·Biochemical and Biophysical Research Communications·Peter StoilovStefan Stamm
Apr 12, 2005·Neuron·Xi ChenDavid D Ginty
Jan 18, 2006·Clinical Science·Moses V ChaoFrancis S Lee
Feb 2, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jackelyn A AlvaM Luisa Iruela-Arispe
Feb 28, 2006·Biochemical and Biophysical Research Communications·Koji OhiraMotoharu Hayashi
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Stefan WieseMichael Sendtner
Jul 8, 2008·Journal of Molecular and Cellular Cardiology·Jens KockskämperMartin D Bootman
Jan 13, 2009·Nature Neuroscience·Jianmin YangBarbara L Hempstead
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura Carim-ToddLino Tessarollo
Jun 6, 2009·Nature Reviews. Neurology·Chiara Zuccato, Elena Cattaneo
Aug 8, 2009·Journal of Molecular and Cellular Cardiology·Jean-Pierre BenitahAna María Gómez
Feb 15, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·François TournouxMarielle Scherrer-Crosbie
Mar 2, 2011·Nature Reviews. Drug Discovery·Alan H Nagahara, Mark H Tuszynski
Aug 26, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catharine G ClarkDavid D Kline
Aug 27, 2013·Nature Reviews. Drug Discovery·Frank M Longo, Stephen M Massa
Feb 6, 2014·PloS One·Agustin AnastasiaPouneh Kermani
Mar 29, 2014·Handbook of Experimental Pharmacology·B LuY Lu
Mar 29, 2014·Handbook of Experimental Pharmacology·Costanza EmanueliBeth A Habecker
Mar 29, 2014·Handbook of Experimental Pharmacology·A Rosenthal, J C Lin
Sep 16, 2014·Frontiers in Cellular Neuroscience·Maryna Baydyuk, Baoji Xu
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ning FengNazareno Paolocci

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Citations

Aug 20, 2016·F1000Research·Mark Bothwell
Oct 13, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Heow Won LeeFrans H H Leenen
Aug 2, 2017·The Journal of Veterinary Medical Science·Kosuke OtaniHideyuki Yamawaki
Dec 3, 2016·Clinical Science·Mariela MitreMoses V Chao
Apr 25, 2020·Nature Communications·Gianluca FulgenziLino Tessarollo
Jun 20, 2020·Nursing Research·Shannon HallowaySusan J Pressler
Oct 25, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Penghui WeiJianjun Li
May 21, 2019·Frontiers in Physiology·Pouneh Kermani, Barbara Hempstead
Apr 25, 2017·Therapeutic Hypothermia and Temperature Management·Moman A MohammadDavid Erlinge
Dec 29, 2020·Experimental Neurology·Sudhirkumar YanpallewarLino Tessarollo
Oct 15, 2020·International Journal of Molecular Sciences·Frank J RaucciCristi L Galindo
Jul 3, 2021·International Journal of Molecular Sciences·Marcus NegronCristi L Galindo
Apr 20, 2018·Journal of Medicinal Chemistry·Sharan K BagalJoseph S Warmus
Sep 22, 2021·Blood Advances·Imane BoukhatemMarie Lordkipanidzé

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BETA
dissection
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transgenic
immunoprecipitation

Software Mentioned

JCB DataViewer
pClamp
ImageJ
Clampfit
Igor

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