BDNF Serum Levels are Associated With White Matter Microstructure in Schizophrenia - A Pilot Study

Frontiers in Psychiatry
Christine HammansThomas Nickl-Jockschat

Abstract

Brain derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of schizophrenia. As BDNF regulates axonal and dendritic growth, altered BDNF levels in schizophrenia patients might underlie changes in structural connectivity that have been identified by magnetic resonance imaging (MRI). We investigated a possible correlation between BDNF serum levels, fiber tract architecture, and regional grey matter volumes in 19 schizophrenia patients and a gender- and age-matched control group. Two patients had to be excluded due to abnormalities in their MRI scans. Serum samples were obtained to determine BDNF levels, and T1- as well as diffusion-weighted sequences were acquired. We, then, investigated correlations between BDNF serum levels with neuroimaging parameters, using Voxel-based Morphometry (VBM) and Tract-based Spatial Statistics (TBSS). We found a significant negative correlation between BDNF serum levels and FA values in the right inferior fronto-occipital fasciculus and the right superior longitudinal fasciculus. These regions also showed a decrease in AD values in schizophrenia patients. Grey matter volumes were reduced in patients but there was no correlation between regional grey matter volumes and BDNF....Continue Reading

References

Jan 1, 1990·Modern Problems of Pharmacopsychiatry·N C Andreasen
Jul 1, 1982·Archives of General Psychiatry·N C Andreasen
Oct 27, 1995·Science·H Thoenen
Jan 1, 1993·Schizophrenia Bulletin·N C Andreasen, W T Carpenter
May 4, 1999·Acta Psychiatrica Scandinavica. Supplementum·K J Friston
Oct 26, 1999·IEEE Transactions on Medical Imaging·D RueckertD J Hawkes
Nov 9, 2002·Journal of Neurophysiology·Fernando Gómez-PinillaV Reggie Edgerton
Dec 19, 2002·NMR in Biomedicine·Mark A Horsfield, Derek K Jones
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Dec 9, 2004·Neurobiology of Aging·Marek LommatzschJohann Christian Virchow
Jul 19, 2005·Journal of Psychiatric Research·Marek KubickiMartha E Shenton
Jan 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shu-Wei SunSheng-Kwei Song
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Louis F Reichardt
Feb 20, 2007·Schizophrenia Research·Peter F BuckleySahebarao Mahadik
Feb 23, 2007·The International Journal of Neuropsychopharmacology·Natalya A UranovaDiana D Orlovskaya
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Paul MackinI Nicol Ferrier
Aug 19, 2007·Brain : a Journal of Neurology·Gwenaëlle DouaudAnthony James
Sep 1, 2007·NeuroImage·John Ashburner
Dec 7, 2007·British Journal of Pharmacology·A L CarvalhoC B Duarte
Feb 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pedro BekinschteinJorge H Medina
Apr 25, 2008·The Journal of Endocrinology·Silvia BegliuominiAndrea R Genazzani
Jan 9, 2009·Schizophrenia Research·Ian Ellison-Wright, Ed Bullmore
Dec 18, 2009·Histology and Histopathology·Tadahiro NumakawaHiroshi Kunugi
Jan 21, 2010·Psychological Medicine·J Moncrieff, J Leo
Jan 26, 2010·Schizophrenia Research·Ripu D JindalMatcheri S Keshavan
Apr 3, 2010·The American Journal of Psychiatry·David M GardnerRoss J Baldessarini
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kirk I EricksonArthur F Kramer
Oct 13, 2010·Molecular Psychiatry·T Nickl-Jockschat, T M Michel
Jan 5, 2011·NeuroImage·Ming-Chang ChiangPaul M Thompson
Feb 9, 2011·Archives of General Psychiatry·Beng-Choon HoVincent Magnotta
May 3, 2011·PloS One·Muhammad Farid Abdul-RahmanKang Sim
Sep 13, 2011·European Archives of Psychiatry and Clinical Neuroscience·Thomas Nickl-JockschatSimon B Eickhoff

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Methods Mentioned

BETA
enzyme linked immunosorbent assays
blood draw

Software Mentioned

FNIRT
TBSS [ Tract - Based Spatial Statistics
dcm2nii
SPM
FSL
TBSS
BET
FSL randomise
SPSS
FDT

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