BDNF signaling during the lifetime of dendritic spines.

Cell and Tissue Research
Marta ZagrebelskyMartin Korte

Abstract

Dendritic spines are tiny membrane specialization forming the postsynaptic part of most excitatory synapses. They have been suggested to play a crucial role in regulating synaptic transmission during development and in adult learning processes. Changes in their number, size, and shape are correlated with processes of structural synaptic plasticity and learning and memory and also with neurodegenerative diseases, when spines are lost. Thus, their alterations can correlate with neuronal homeostasis, but also with dysfunction in several neurological disorders characterized by cognitive impairment. Therefore, it is important to understand how different stages in the life of a dendritic spine, including formation, maturation, and plasticity, are strictly regulated. In this context, brain-derived neurotrophic factor (BDNF), belonging to the NGF-neurotrophin family, is among the most intensively investigated molecule. This review would like to report the current knowledge regarding the role of BDNF in regulating dendritic spine number, structure, and plasticity concentrating especially on its signaling via its two often functionally antagonistic receptors, TrkB and p75NTR. In addition, we point out a series of open points in which, wh...Continue Reading

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Citations

Sep 19, 2020·Cell and Tissue Research·Tanja Brigadski, Volkmar Leßmann
Sep 26, 2020·Cell and Tissue Research·Mart SaarmaVolkmar Leßmann
Dec 4, 2020·Neural Regeneration Research·Dae Young YooIn Koo Hwang
Oct 25, 2020·International Journal of Molecular Sciences·Luca Colucci-D'AmatoFloriana Volpicelli
Oct 30, 2020·Nature and Science of Sleep·Ping ZhangFang Wang
May 25, 2021·Frontiers in Pharmacology·Frank Adu-NtiXin-Ming Ma
May 29, 2021·Neuropharmacology·Daniel D Cooper, Bruno G Frenguelli
Jul 2, 2021·Brain Research Bulletin·Mengjuan ShangGuozhen Guo

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Methods Mentioned

BETA
nucleotide exchange
fluorescence resonance
GTPase
GTPases

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