BDNF up-regulates TrkB protein and prevents the death of CA1 neurons following transient forebrain ischemia.

Brain Pathology
I FerrerE Arenas

Abstract

The neurotrophin family of growth factors, which includes Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT3) and Neurotrophin-4/5 (NT4/5) bind and activate specific tyrosine kinase (Trk) receptors to promote cell survival and growth of different cell populations. For these reasons, growing attention has been paid to the use of neurotrophins as therapeutic agents in neurodegeneration, and to the regulation of the expression of their specific receptors by the ligands. BDNF expression, as revealed by immunohistochemistry, is found in the pre-subiculum, CA1, CA3, and dentate gyrus of the hippocampus. Strong TrkB immunoreactivity is present in most CA3 neurons but only in scattered neurons of the CA1 area. Weak TrkB immunoreactivity is found in the granule cell layer of the dentate gyrus. Unilateral grafting of BDNF-transfected fibroblasts into the hippocampus resulted in a marked increase in the intensity of the immunoreaction and in the number of TrkB-immunoreactive neurons in the granule cell layer of the dentate gyrus, pre-subiculum and CA1 area in the vicinity of the graft. No similar effects were produced after the injection of control mock-transfected fibroblasts. Delayed cell death in t...Continue Reading

References

Sep 7, 1995·Annals of the New York Academy of Sciences·M Barbacid
Jan 1, 1995·Annual Review of Neuroscience·M Bothwell
Jan 16, 1995·The Journal of Comparative Neurology·D E Wright, W D Snider
Nov 1, 1994·Journal of Neurobiology·C F Ibáñez
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BeckA Wree
Aug 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L AcarinB Castellano
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z KokaiaO Lindvall
Jun 1, 1993·Progress in Neurobiology·H HaraK Kogure
Sep 1, 1995·The European Journal of Neuroscience·M M Dugich-DjordjevicF Hefti
Jan 1, 1996·Annual Review of Neuroscience·G R Lewin, Y A Barde

❮ Previous
Next ❯

Citations

Mar 10, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G Heinrich, T Lum
Feb 13, 2002·Molecular Psychiatry·M VentrigliaM Gennarelli
Jun 22, 2006·Neurotoxicity Research·M Vidal-SanzM P Villegas-Perez
Aug 30, 2008·Journal of Neurochemistry·Feng Zhang, Jun Chen
Sep 17, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Kerry RennieMahmud Bani-Yaghoub
Jan 19, 2018·Aging and Disease·Wei LiangWenqiang Chen
Dec 30, 2017·Experimental and Therapeutic Medicine·Shun ZouLili Ban
Dec 3, 1999·American Journal of Medical Genetics·T H WassinkN C Andreasen
May 3, 2006·Cerebrovascular Diseases·Isidro Ferrer
Jun 5, 2010·Journal of Medicinal Food·Ki-Yeon YooMoo-Ho Won
Sep 20, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Yu-Jie Chiou, Tiao-Lai Huang
Oct 3, 1999·Physiological Reviews·P Lipton
Jul 12, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaoqing SongLing Li
Jul 10, 2020·The Journal of International Medical Research·Yanan SunYu Qin
Jul 2, 2019·Journal of Neuroscience Research·Hanna KletkiewiczJustyna Rogalska
Oct 31, 2002·The European Journal of Neuroscience·L A KarchewskiV M K Verge
Apr 21, 1999·Brain Research. Brain Research Reviews·M WaltonM Dragunow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.