BDNF upregulation during declarative memory formation in monkey inferior temporal cortex

Nature Neuroscience
Wataru TokuyamaYasushi Miyashita


In primates, visual long-term memory of objects is presumably stored in the inferior temporal (IT) cortex. Because brain-derived neurotrophic factor (BDNF) is involved in activity-dependent neural reorganization, we tested the hypothesis that BDNF would be upregulated in IT cortex during formation of visual pair-association memory. To eliminate genetic and cognitive variations between individual animals, we used split-brain monkeys for intra-animal comparison in PCR-based mRNA quantitation. The monkeys learned a pair-association (PA) task using one hemisphere and a control visual task using the other, to balance the amount of visual input. We found that BDNF was upregulated selectively in area 36 of IT cortex during PA learning, but not in areas involved in earlier stages of visual processing. In situ hybridization showed that BDNF-expressing cells were localized in a patchlike cluster. The results suggest that BDNF contributes to reorganization of neural circuits for visual long-term memory formation in the primate.


Jul 12, 2002·Journal of Neuroscience Research·Nicole C BerchtoldCarl W Cotman
Dec 31, 2009·Cellular and Molecular Neurobiology·I Lista, G Sorrentino
Jul 22, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Li-Chin Ou, Po-Wu Gean
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Takashi KawashimaHaruhiko Bito
Mar 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Takahiro OsadaYasushi Miyashita
Oct 6, 2005·Learning & Memory·Mariana AlonsoJorge H Medina
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dong Ya ZhuYou Ming Lu
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masatoshi YoshidaYasushi Miyashita
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·Anne E WestMichael E Greenberg
Dec 6, 2003·The European Journal of Neuroscience·Yuji NayaYasushi Miyashita
Apr 11, 2003·Primates; Journal of Primatology·Takuma MoriMotoharu Hayashi
Dec 31, 2005·Journal of Neuroscience Research·Irena MalkovskaLuis F Parada
Aug 21, 2012·Nature Reviews. Immunology·Jonathan KipnisNoël C Derecki
May 18, 2007·Journal of Neurochemistry·Floriana VolpicelliUmberto di Porzio
Jan 22, 2008·Human Molecular Genetics·Tasuku NomuraIzuho Hatada
Mar 31, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·L N SaliganR Machado-Vieira
May 15, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Javier Cortés-MendozaLeonor Pérez-Martínez
Aug 25, 2017·PloS One·Stuart D PortburyPaul A Adlard
Aug 12, 2015·Wiley Interdisciplinary Reviews. Cognitive Science·Yvette N LambIan J Kirk
Jun 27, 2019·International Journal of Molecular Sciences·Da-Tong JuChih-Yang Huang
Mar 11, 2016·Physiological Reviews·Martin Korte, Dietmar Schmitz
Jan 18, 2006·Clinical Science·Shelley J Allen, David Dawbarn
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jocelyne Bachevalier


Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E CastrénD Lindholm
Nov 20, 1992·Brain Research. Developmental Brain Research·G W HuntleyP J Isackson
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Nov 14, 1991·Nature·K Sakai, Yasushi Miyashita
Jan 1, 1989·Neuropsychologia·R Fendrich, M S Gazzaniga
Dec 1, 1987·Journal of Consulting and Clinical Psychology·M Mitchell
Aug 1, 1973·The Journal of Comparative Neurology·J StoneS M Sherman
Oct 27, 1995·Science·H Thoenen
Jan 23, 1995·Behavioural Brain Research·E T Rolls
Jan 12, 1995·Nature·S A NeeperCarl W Cotman
Nov 1, 1994·Journal of Neurobiology·M Barbacid
Jan 1, 1993·Annual Review of Neuroscience·Yasushi Miyashita
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Higuchi, Yasushi Miyashita
Feb 1, 1996·Current Opinion in Neurobiology·T Bonhoeffer
Jan 1, 1996·Annual Review of Neuroscience·G R Lewin, Y A Barde
Jun 1, 1997·Brain Research. Molecular Brain Research·M DragunowW C Abraham
Nov 22, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M MishkinF Vargha-Khadem
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Dec 11, 1999·Brain Research. Brain Research Protocols·Wataru TokuyamaYasushi Miyashita
Jan 21, 2000·Learning & Memory·E A BuffaloS M Zola
Feb 7, 2001·Current Opinion in Neurobiology·Yasushi Miyashita, T Hayashi
Jun 9, 2000·Annual Review of Neuroscience·S J MartinR G Morris
Apr 17, 2001·The Behavioral and Brain Sciences·J P Aggleton, M W Brown

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