BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study.

Addiction Biology
Mark K GreenwaldMargit Burmeister

Abstract

Brain-derived neurotrophic factor (BDNF) Val(66)Met genotype has been associated with neurobehavioral deficits. To examine its relevance for addiction, we examined BDNF genotype differences in drug-seeking behavior. Heroin-dependent volunteers (n = 128) completed an interview that assessed past-month naturalistic drug-seeking/use behaviors. In African Americans (n = 74), the Met allele was uncommon (carrier frequency 6.8%); thus, analyses focused on European Americans (n = 54), in whom the Met allele was common (carrier frequency 37.0%). In their natural setting, Met carriers (n = 20) reported more time- and cost-intensive heroin-seeking and more cigarette use than Val homozygotes (n = 34). BDNF Val(66)Met genotype predicted 18.4% of variance in 'weekly heroin investment' (purchasing time × amount × frequency). These data suggest that the BDNF Met allele may confer a 'preferred drug-invested' phenotype, resistant to moderating effects of higher drug prices and non-drug reinforcement. These preliminary hypothesis-generating findings require replication, but are consistent with pre-clinical data that demonstrate neurotrophic influence in drug reinforcement. Whether this genotype is relevant to other abused substances besides opio...Continue Reading

References

Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·L Sklair-TavronE J Nestler
Dec 20, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G F Koob, M Le Moal
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Apr 12, 2003·Trends in Neurosciences·Gregory L GerdemanDavid M Lovinger
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lin LuYavin Shaham
Mar 6, 2004·Neuromolecular Medicine·Carlos A Bolaños, Eric J Nestler
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lukas PezawasDaniel R Weinberger
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Sachio MatsushitaSusumu Higuchi
Aug 20, 2005·Brain Research. Molecular Brain Research·Chih-Ya ChengShih-Jen Tsai
Sep 10, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Joke BeutenMing D Li
Jan 31, 2006·Biological Psychiatry·Joshua A BuellerJon-Kar Zubieta
Apr 15, 2006·CNS & Neurological Disorders Drug Targets·P SokoloffC Gross
Dec 23, 2006·Psychopharmacology·Undine E LangJürgen Gallinat
Dec 7, 2007·British Journal of Pharmacology·A L CarvalhoC B Duarte
Dec 14, 2007·Annals of the New York Academy of Sciences·Robert H Lipsky, Ann M Marini
Apr 22, 2008·Addiction·Francesca Ducci, David Goldman
May 15, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Colin A HodgkinsonDavid Goldman
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chloe C Y Wong, Gunter Schumann
Jul 24, 2008·Neuropharmacology·Scott J RussoEric J Nestler
Sep 27, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mary-Anne EnochDavid Goldman
Jan 28, 2009·Alcoholism, Clinical and Experimental Research·Marcin WojnarMargit Burmeister
Feb 25, 2009·Nature Reviews. Genetics·Ming D Li, Margit Burmeister
Mar 4, 2009·Molecular Psychiatry·T L PetryshenP Sklar
Mar 5, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nancy L SacconeLaura J Bierut
May 30, 2009·Science·Hector Vargas-PerezDerek van der Kooy
Jun 12, 2009·The Journal of Headache and Pain·Cherubino Di LorenzoFrancesco Pierelli
Nov 27, 2009·Substance Use & Misuse·Juliette Roddy, Mark Greenwald
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Jibran Y KhokharRachel F Tyndale
Mar 6, 2010·Annals of the New York Academy of Sciences·Vadim YuferovMary Jeanne Kreek
Apr 27, 2010·Nature Genetics·UNKNOWN Tobacco and Genetics Consortium
May 12, 2010·Annals of Human Genetics·Gabriela NovakBernard Le Foll
Mar 30, 2011·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Juliette RoddyMark K Greenwald

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Citations

May 22, 2013·Neuropharmacology·N D Volkow, R D Baler
Nov 6, 2013·Pharmacology & Therapeutics·George R UhlF Scott Hall
Jun 1, 2014·Drug and Alcohol Dependence·Mark K Greenwald, Caren L Steinmiller
Oct 4, 2014·Addictive Behaviors·Jamey J ListerMark K Greenwald
Jan 28, 2015·Drug and Alcohol Dependence·Matthew J WorleyWalter Ling
Jul 12, 2016·Journal of Neurotrauma·Michael N DretschGrant L Iverson
Aug 5, 2017·Neurotoxicity Research·Alessia BachisItalo Mocchetti
Apr 25, 2019·The American Journal on Addictions·Cara A StrubleLeslie H Lundahl
Feb 6, 2020·Molecular Psychiatry·Nora D Volkow, Carlos Blanco
Mar 21, 2021·Journal of Neurochemistry·Gino P AsuniItalo Mocchetti

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