BDNF val66met polymorphism and depressive disorders in patients with acute coronary syndrome

Journal of Affective Disorders
Hee-Ju KangJae-Min Kim

Abstract

Brain-derived neurotrophic factor (BDNF) may be the key to understanding the development of depression in patients with acute coronary syndrome (ACS), as it is associated with both conditions. Because the expression of BDNF is influenced by genetic polymorphisms, in this study we investigated the association between the BDNF polymorphism val66met and both the risk of depression in ACS and the treatment response. Among the 969 patients with recent ACS at baseline, 711 were re-evaluated after 1 year of follow-up. Depressive disorder status was assessed according to the DSM-IV criteria both at baseline and at follow-up. Baseline prevalence, follow-up incidence, and the persistence of depression were also determined. Of the 378 patients diagnosed with depression at baseline, 255 were randomized to a 24-week double-blind placebo-controlled trial of escitalopram; the remaining 123 received the usual care. Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models. The prevalence and persistence, but not the incidence of depressive disorders were significantly associated with BDNF met alleles. Patients in the escitalopram group who carried th...Continue Reading

References

Aug 1, 1989·Archives of Internal Medicine·S J SchleiferH D Zucker
Apr 2, 2003·Neuroscience and Biobehavioral Reviews·Angela J Grippo, Alan Kim Johnson
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jun 9, 2004·Psychosomatic Medicine·Heather S LettMark F Newman
Jun 15, 2005·Psychosomatic Medicine·Robert M CarneyRichard C Veith
Jul 20, 2005·Journal of Psychosomatic Research·Titia A SpijkermanJohan Ormel
Oct 8, 2005·American Heart Journal·Daisaku NakataniUNKNOWN Osaka Acute Coronary Insufficiency Study Group
Jan 21, 2006·Journal of General Internal Medicine·Brett D ThombsRoy C Ziegelstein
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arvind GovindarajanSumantra Chattarji
Jan 16, 2007·Neurobiology of Aging·Jae-Min KimJin-Sang Yoon
May 8, 2007·Trends in Cardiovascular Medicine·Pouneh Kermani, Barbara Hempstead
Aug 2, 2007·Therapeutic Drug Monitoring·Sang Seop LeeJae-Gook Shin
Jan 25, 2008·Gender Medicine·Tasneem Z NaqviSyed S A Naqvi
Apr 5, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Priscila S RibeiroClaudia Garcia-Moreno
Jul 12, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jeanne M McCafferyMarie-Pierre Dubé
Nov 18, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rajiv T Erasmus
Dec 28, 2011·Journal of Psychosomatic Research·Baiba Hedegaard HansenMorten Birket-Smith
May 23, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yu PeiXin Ma
Jun 5, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomihisa NiitsuAlessandro Serretti
Jan 2, 2015·Journal of Affective Disorders·Maryna PolyakovaMatthias L Schroeter
Mar 17, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jae-Min KimJin-Sang Yoon
Apr 29, 2015·Chonnam Medical Journal·Hee-Ju KangJae-Min Kim

❮ Previous
Next ❯

Citations

Jun 2, 2017·JCI Insight·Rui-Sheng WangJoseph Loscalzo
Feb 27, 2018·Topics in Stroke Rehabilitation·Margaret A FrenchDarcy S Reisman
Jun 25, 2019·Frontiers in Neurology·Yang JinSong Bai Xu
Nov 25, 2020·Journal of Molecular Neuroscience : MN·Tarapati RanaSimona Bungau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.