BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia

The American Journal of Psychiatry
Takanori Hashimoto, D A Lewis

Abstract

In the prefrontal cortex of subjects with schizophrenia, decreased signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase (TrkB) appears to contribute to the reduced expression of mRNA encoding the 67-kilodalton isoform of glutamate decarboxylase (GAD(67)), an enzyme for GABA synthesis. The authors examined in subjects with schizophrenia the effect in the human BDNF gene of a single nucleotide polymorphism (Val66Met), which reduces the trafficking and secretion of BDNF protein, on the expression of GAD(67) mRNA. BDNF Val66Met genotyping was performed in 27 matched pairs of schizophrenia and comparison subjects. The impact of this polymorphism on prefrontal cortex GAD(67) mRNA expression in schizophrenia subjects was assessed by comparing within-pair differences in GAD(67) mRNA expression between schizophrenia subjects with versus without the Met66 allele after the level of BDNF mRNA expression was controlled. In contrast to expectations, the within-pair reduction in GAD(67) mRNA expression was not greater in schizophrenia subjects who were hetero- or homozygous for the Met66 allele. These subjects did tend to exhibit less marked within-pair reductions in both GAD(67) and BDNF mRNA expres...Continue Reading

Citations

Nov 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco MatriscianoAlessandro Guidotti
Oct 26, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Grazyna RajkowskaJose Javier Miguel-Hidalgo
Aug 27, 2010·Cerebral Cortex·Carlos Sánchez-Huertas, Beatriz Rico
Jan 13, 2011·Journal of Psychiatry & Neuroscience : JPN·Mia Thompson RayMaree J Webster
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Sep 2, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·F ZarrilliM Sarchiapone
Jan 24, 2015·The International Journal of Neuropsychopharmacology·Wolfgang StrubeAlkomiet Hasan
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Methods Mentioned

BETA
PCR
genotyping

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