Beagle puppy model of intraventricular hemorrhage

Journal of Neurosurgery
L R MentR Lambrecht


Intraventricular hemorrhage (IVH) is a major neurological problem of the preterm infant and originates in the germinal matrix tissues of the developing brain. The newborn beagle pup has been demonstrated to provide an excellent model for this neonatal neuropathological condition. By the production of hemorrhagic hypotension followed by relative volume reexpansion, such hemorrhages can be produced in this animal. Carbon-14 (14C)-iodoantipyrine was used for measuring the cerebral blood flow in this experimental model and demonstrated that, although the germinal matrix is a relatively low-flow area in the newborn beagle pup, the selective flow to this region increases significantly in animals with IVH.


Jun 1, 1979·Archives of Disease in Childhood·M FujimuraJ P Tizard
Nov 22, 1979·The New England Journal of Medicine·M HackI R Merkatz
Jul 1, 1978·Early Human Development·J S Wigglesworth, K E Pape
Apr 1, 1978·The Journal of Pediatrics·Joseph J Volpe
Mar 1, 1977·Archives of Disease in Childhood·P EmersonJ P Tizard
Jun 1, 1977·Archives of Disease in Childhood·J S WigglesworthS A Slade
Sep 1, 1976·Archives of Disease in Childhood·G Hambleton, J S Wigglesworth
Jul 1, 1972·Physiological Reviews·E Betz
Jun 1, 1974·Circulation Research·N A Lassen
Jun 1, 1970·Neurology·C KennedyL Sokoloff
Jan 1, 1981·Archives of Environmental Contamination and Toxicology·C J Cappon, J C Smith
Feb 17, 1980·Brain Research·M J HernándezG S Bowman


Oct 1, 1991·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·N YamashitaH Nagai
Feb 1, 1984·Prostaglandins·L R MentC C Duncan
Jul 20, 1992·Neuroscience Letters·A Pavlík, V Mares
Oct 20, 1998·Seminars in Pediatric Neurology·Jeffrey M Perlman
Jan 10, 2004·Antioxidants & Redox Signaling·Donough J O'Donovan, Caraciolo J Fernandes
Dec 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·R W Hunt
Nov 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·N Evans, Martin Kluckow
May 5, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·Martin Kluckow, N Evans
Sep 12, 2009·Journal of Child Neurology·Adré J du Plessis
Apr 1, 1986·Journal of Neurosurgery·E G FischerC S Kerr
May 10, 2008·Journal of Neurosurgery·Kristian AquilinaMarianne Thoresen
Jul 31, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·W-H LimP-H Yang
Nov 1, 1994·European Journal of Pediatrics·J U GrönlundI A Välimäki
Sep 16, 2015·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Marco Matthias HeftiHannah C Kinney
Nov 8, 2005·Experimental Neurology·Janani BalasubramaniamMarc R Del Bigio
Jun 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kristen EmpieSandra E Juul
Oct 22, 2013·Progress in Neurobiology·Guohua XiRichard F Keep
Jul 1, 1987·Journal of Child Neurology·J Goddard-Finegold, E M Mizrahi
Apr 30, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Akio Ishiguro
Oct 27, 2017·Expert Opinion on Therapeutic Targets·Thomas GartonRichard F Keep
Jan 1, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·J R KaiserD K Williams
Mar 1, 1991·Stroke; a Journal of Cerebral Circulation·L R MentJ A Madri
Aug 1, 1992·Stroke; a Journal of Cerebral Circulation·L R MentJ A Madri
Oct 11, 2008·Stroke; a Journal of Cerebral Circulation·Paraskevi GeorgiadisPraveen Ballabh
Mar 2, 2010·Journal of Korean Medical Science·Juyoung LeeJung-Hwan Choi
Mar 18, 2005·Neuropathology and Applied Neurobiology·John A AnstromWilliam R Brown
Sep 28, 2004·Brain Pathology·Shobha CherianSeth Love
Jun 20, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Juyoung LeeJung Hyun Lee
Aug 12, 2006·Journal of Child Neurology·Janani Balasubramaniam, Marc R Del Bigio

Related Concepts

Iodoantipyrine, 131I-labeled
Cerebral Hemorrhage
Structure of Interventricular Foramen
Cerebrovascular Circulation
Canis familiaris

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.