PMID: 11931470Apr 5, 2002Paper

Beam configurations for 3D tomographic intensity modulated radiation therapy

Physics in Medicine and Biology
Robert Y Levine, Matthew Braunstein

Abstract

We extend the theory of three-dimensional (3D) tomographic intensity modulated radiation therapy (IMRT). The geometry consists of two-dimensional modulated beams on a sphere centred in the tumour. The theory provides an efficient algorithm for computing beam modulation patterns that approximately 'reconstruct' the prescribed dose function. In this paper optimum beam numbers are estimated from dose function spherical harmonics using the 3D projection-slice theorem. An extension to three dimensions of the 'Bow Tie' criterion for beam numbers is derived. The effects of insufficient beam front sampling and beam numbers are characterized with a configuration-dependent matrix. Factors that independently increase beam numbers, such as tumour size and shape, are related to the spherical harmonic content in the dose function. Examples of tomographic IMRT reconstruction with a 3D concave tumour are given.

References

Oct 1, 1990·Physics in Medicine and Biology·T BortfeldW Schlegel
Jan 1, 1988·Physics in Medicine and Biology·T R MackieJ J Battista
Apr 1, 1987·International Journal of Radiation Oncology, Biology, Physics·A M Cormack
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·T BortfeldT J Waldron
Jan 15, 1994·International Journal of Radiation Oncology, Biology, Physics·J D Bourland, K P McCollough
Feb 1, 1993·Physics in Medicine and Biology·T Bortfeld, W Schlegel
May 8, 1999·Physics in Medicine and Biology·U Oelfke, T Bortfeld
Jan 21, 2000·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·M Braunstein, R Y Levine
Mar 4, 2000·Physics in Medicine and Biology·M Braunstein, R Y Levine

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