Beam energy considerations for gold nano-particle enhanced radiation treatment

Physics in Medicine and Biology
Frank Van den HeuvelS Nuyts

Abstract

A novel approach using nano-technology enhanced radiation modalities is investigated. The proposed methodology uses antibodies labeled with organically inert metals with a high atomic number. Irradiation using photons with energies in the kilo-electron volt (keV) range shows an increase in dose due to a combination of an increase in photo-electric interactions and a pronounced generation of Auger and/or Coster-Krönig (A-CK) electrons. The dependence of the dose deposition on various factors is investigated using Monte Carlo simulation models. The factors investigated include agent concentration, spectral dependence looking at mono-energetic sources as well as classical bremsstrahlung sources. The optimization of the energy spectrum is performed in terms of physical dose enhancement as well as the dose deposited by Auger and/or Coster-Krönig electrons and their biological effectiveness. A quasi-linear dependence on concentration and an exponential decrease within the target medium is observed. The maximal dose enhancement is dependent on the position of the target in the beam. Apart from irradiation with low-photon energies (10-20 keV) there is no added benefit from the increase in generation of Auger electrons. Interestingly, a...Continue Reading

References

May 1, 1997·International Journal of Radiation Biology·H NikjooM Terrissol
Oct 31, 2001·European Journal of Nuclear Medicine·M CybullaAndreas Otte
Mar 29, 2002·Lancet·Andreas OtteMarkus Cybulla
Apr 3, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Thomas M BehrDavid M Goldenberg
May 11, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Tilmann SchumacherHelmut Maecke
Aug 11, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Miklos PlessJan Mueller-Brand
Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
May 7, 2005·Physics in Medicine and Biology·P BaldelliM Gambaccini
Jul 21, 2005·Physics in Medicine and Biology·F VerhaegenDimitre Hristov
Mar 23, 2006·Physics in Medicine and Biology·V A Semenenko, R D Stewart
Sep 15, 2007·The Journal of Physical Chemistry. B·Joshua D CarterTing Guo
Jun 3, 2008·Advanced Drug Delivery Reviews·Matthias MiedererMichael R McDevitt
Jun 28, 2008·Radiation Research·Pichumani BalagurumoorthyAmin I Kassis
Dec 9, 2008·International Journal of Radiation Biology·Jing Chen
May 30, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Wan Nordiana RahmanMoshi Geso

Citations

Jun 16, 2012·Australasian Physical & Engineering Sciences in Medicine·Mohammad Taghi Bahreyni ToossiAli Soleimani Meigooni
Mar 23, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Panagiotis TsiamasPiotr Zygmanski
Jul 1, 2014·Nanomedicine·Wilfred NgwaG Mike Makrigiorgos
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Mansour Zabihzadeh, Sahar Arefian
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·N Z Noor AzmanI M Low
Feb 13, 2014·International Journal of Radiation Biology·Ya-Yun HsiaoChuan-Jong Tung
Apr 22, 2016·Applied Microbiology and Biotechnology·Deena TitusSelvaraj Mohana Roopan
Oct 30, 2014·Frontiers in Chemistry·Daniel R CooperJay L Nadeau
Dec 7, 2016·International Journal of Radiation Biology·Shokouhozaman SoleymanifardAmeneh Sazgarnia
Jan 20, 2018·Oncotarget·Eun Ho KimMyonggeun Yoon
Sep 22, 2012·Physics in Medicine and Biology·Wilfred NgwaRoss I Berbeco
May 5, 2018·Advanced Healthcare Materials·Myriam Laprise-PelletierMarc-André Fortin

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