PMID: 11325446Apr 28, 2001Paper

Beam-orientation optimization of intensity-modulated radiotherapy: clinical application to parotid gland tumours

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
C RowbottomS Webb

Abstract

An optimization algorithm has been developed to determine the best beam-arrangement for a small number of intensity-modulated radiotherapy (IMRT) fields. The algorithm is designed to avoid, if possible, beam-orientations that pass through organs-at-risk (OARs) with low radiation tolerance. An independent, fast IMRT algorithm based on the Bortfeld algorithm was developed to determine the profile of the intensity-modulated beams (IMBs) for each beam-arrangement and a fast-simulated-annealing algorithm finds the 'optimal' beam-arrangement. The final beam-arrangement was transferred to the CORVUS (NOMOS Corporation) treatment planning system, and the IMBs were re-optimized for comparison with a standard nine-field, equi-spaced arrangement. The algorithm has been initially tested on a single example patient, with a parotid gland carcinoma. The nine-field, IMRT plan for an example patient with a parotid gland tumour significantly reduced the dose to the cochlea compared with the conformal radiotherapy plan. In addition, the planning-target-volume (PTV) homogeneity was improved, but the plan produced a higher dose to the contralateral parotid (73% of the OAR received more than 6 Gy). The beam-orientation optimization algorithm produce...Continue Reading

References

May 1, 1992·Clinical Oncology : a Journal of the Royal College of Radiologists·R P SymondsT Azhar
Jul 1, 1991·Clinical Oncology : a Journal of the Royal College of Radiologists·I P Singh, N J Slevin
Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·C GrauO Elbrønd
Jun 1, 1990·International Journal of Radiation Oncology, Biology, Physics·C A NorthM E Johns
Oct 1, 1990·Physics in Medicine and Biology·T BortfeldW Schlegel
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·S Söderström, A Brahme
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·A J SykesN K Gupta
Sep 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R MohanC C Ling
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·T BortfeldT J Waldron
Sep 2, 1998·Physics in Medicine and Biology·O C HaasJ A Mills
Nov 14, 1998·Physics in Medicine and Biology·S WebbP M Evans
Feb 1, 1997·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

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Citations

Feb 10, 2007·Current Oncology Reports·Joseph M Scianna, Guy J Petruzzelli
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bram van AsselenCornelis P J Raaijmakers
Mar 19, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Catharine H ClarkChristopher M Nutting
Jul 6, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C M NuttingS Webb
Nov 3, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C M NuttingS Webb
Mar 1, 1974·Journal of Maxillofacial Surgery·I Koblin, H Koch
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Shiva DasJulian Rosenman
Feb 10, 2011·Medical Physics·R VaitheeswaranVikram Maiya
Apr 28, 2011·Medical Physics·Steven van de WaterBen J M Heijmen
Dec 3, 2002·International Journal of Radiation Oncology, Biology, Physics·Andrei Pugachev, Lei Xing
Mar 11, 2004·The British Journal of Radiology·M T Guerrero Urbano, C M Nutting
Sep 25, 2007·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A BouyonM Housset
Sep 11, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter S PotrebkoZoann Nugent
Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Xiaochun WangRadhe Mohan
Sep 3, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frank Saran
May 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Shiva K DasJulian G Rosenman
Oct 3, 2006·Seminars in Radiation Oncology·John D FenwickT Rock Mackie
Mar 8, 2011·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Monica MoldovanKenneth R Hogstrom
Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary Feng, Avraham Eisbruch
Oct 8, 2003·Physics in Medicine and Biology·G MeedtF Nüsslin
Jun 20, 2006·Head & Neck·Lisa van der PuttenC René Leemans
Mar 28, 2008·Physics in Medicine and Biology·Evert WoudstraPascal R M Storchi
Nov 10, 2013·Physics in Medicine and Biology·Gregory SmythJames L Bedford
Jul 5, 2018·Computational and Mathematical Methods in Medicine·Ali GhanbarzadehSeied Rabi Mahdavi
May 12, 2017·Physics in Medicine and Biology·Peter S PotrebkoJan Poleszczuk

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