Beat-by-Beat Estimation of the Left Ventricular Pressure-Volume Loop Under Clinical Conditions

Annals of Biomedical Engineering
Shaun DavidsonJ Geoffrey Chase

Abstract

This paper develops a method for the minimally invasive, beat-by-beat estimation of the left ventricular pressure-volume loop. This method estimates the left ventricular pressure and volume waveforms that make up the pressure-volume loop using clinically available inputs supported by a short, baseline echocardiography reading. Validation was performed across 142,169 heartbeats of data from 11 Piétrain pigs subject to two distinct protocols encompassing sepsis, dobutamine administration and clinical interventions. The method effectively located pressure-volume loops, with low overall median errors in end-diastolic volume of 8.6%, end-systolic volume of 17.3%, systolic pressure of 19.4% and diastolic pressure of 6.5%. The method further demonstrated a low overall mean error of 23.2% predicting resulting stroke work, and high correlation coefficients along with a high percentage of trend compass 'in band' performance tracking changes in stroke work as patient condition varied. This set of results forms a body of evidence for the potential clinical utility of the method. While further validation in humans is required, the method has the potential to aid in clinical decision making across a range of clinical interventions and diseas...Continue Reading

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Citations

Feb 1, 2019·Biomedical Engineering Online·Jacob M KingCharles E Taylor
Aug 10, 2020·Computers in Biology and Medicine·Christian WinklerUlrike Herberg

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