Beat-to-beat QT interval variability is primarily affected by the autonomic nervous system.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Takanao MineMitsumasa Ohyanagi

Abstract

Beat-to-beat QT interval variability is associated with life-threatening arrhythmias and sudden death, however, its precious mechanism and the autonomic modulation on it remains unclear. The purpose of this study was to determine the effect of drugs that modulate the autonomic nervous system on beat-to-beat QT interval. RR and QT intervals were determined for 512 consecutive beats during fixed atrial pacing with and without propranolol and automatic blockade (propranolol plus atropine) in 11 patients without structural heart disease. Studied parameters included: RR, QTpeak (QRS onset to the peak of T wave), QTend (QRS onset to the end of T wave) interval, standard deviation (SD) of the RR, QTpeak, and QTend (RR-SD, QTpeak-SD, and QTend-SD), coefficients of variation (RR- CV, QTpeak-CV, and QTend-CV) from time domain analysis, total power (TP; RR-TP, QTpeak-TP, and QTend-TP), and power spectral density of the low-frequency band (LF; RR-LF, QTpeak-LF, and QTend-LF) and the high-frequency band (HF; RR-HF, QTpeak-HF and QTend-HF). Administration of propranolol and infusion of atropine resulted in the reduction of SD, CV, TP, and HF of the QTend interval when compared to controlled atrial pacing (3.7 +/- 0.6 and 3.5 +/- 0.5 vs 4.8 +...Continue Reading

References

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Citations

Jul 24, 2012·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Muhammad A HasanMathias Baumert
Feb 12, 2010·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Shlomo Stern
Jun 9, 2016·Korean journal of anesthesiology·In Young HuhSoon Eun Park
Jan 30, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mathias BaumertPaul G A Volders
Dec 10, 2014·Therapeutic Advances in Psychopharmacology·Saeed Shoja Shafti, Parisa Fallah Jahromi
Aug 16, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Fatima El-HamadMathias Baumert
Jan 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Mathias BaumertGavin Lambert
Jun 15, 2011·Journal of Athletic Training·Michael F La FountaineWilliam A Bauman
Aug 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Sachin NayyarMathias Baumert

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