Beating the odds: programming proliferation in the mammalian heart

Genome Medicine
Rajan JainJonathan A Epstein

Abstract

The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle control. Recent insights into how myocytes can be coaxed into duplicating in vivo might inform emerging therapeutics.

References

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