PMID: 26328450Sep 4, 2015Paper

Beclomethasone Dipropionate-Loaded Polymeric Nanocapsules: Development, In Vitro Cytotoxicity, and In Vivo Evaluation of Acute Lung Injury

Journal of Nanoscience and Nanotechnology
Janaíne Micheli ChassotLetícia Cruz

Abstract

The aim of this work was to develop polymeric nanocapsules intended for the pulmonary delivery of beclomethasone dipropionate using ethyl cellulose or poly(ε-caprolactone). The formulations showed adequate physicochemical characteristics, namely, average diameter lower than 260 nm, low polydispersity index (< 0.2), negative zeta potential, neutral pH values, and encapsulation efficiencies close to 100%. The thermal analysis by DSC suggested that beclomethasone dipropionate encapsulated in the nanocapsules was in an amorphous state. In addition, both ethyl cellulose and poly(ε-caprolactone) nanocapsules were able to delay the drug photodegradation under UVC radiation. The in vitro drug release showed a prolonged release without burst effect using the dialysis bag diffusion technique. Moreover, ethyl cellulose and poly(ε-caprolactone) nanocapsules presented low in vitro cytotoxicity on 3T3 fibroblasts cells. In vivo, the formulations showed no acute pulmonary injury in rats. Therefore, the developed nanocapsules could be considered suitable carriers to be used for beclomethasone dipropionate pulmonary delivery.

Citations

Sep 8, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Cristina G VenturiniSilvia S Guterres
May 20, 2017·Pharmaceutical Development and Technology·Natháli S PegoraroLetícia Cruz
Dec 26, 2016·Colloids and Surfaces. B, Biointerfaces·D TrioloG Cavallaro
Mar 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Mailine GehrckeLetícia Cruz
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Loanda Aparecida Cabral RudnikSandra Maria Warumby Zanin
May 14, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Setthapong SenaratThawatchai Phaechamud

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