BECN1 is a new driver of ferroptosis

Autophagy
Rui KangDaolin Tang

Abstract

Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a catabolic process of degradation induced by starvation or other stressors. Our recent findings reveal a novel alternative mechanism by which BECN1 can promote ferroptosis through the regulation of activity of the cysteine and glutamate antiporter system xc- in cancer cells. BECN1-dependent autophagy requires the formation of the BECN1-containing class III phosphatidylinositol 3-kinase (PtdIns3K) complex, whereas BECN1-dependent ferroptosis requires the formation of a BECN1-SLC7A11 complex. Furthermore, AMP-activated protein kinase (AMPK) is required for BECN1 phosphorylation to trigger formation of the BECN1-SLC7A11 complex in the process of inhibiting system xc- activity and inducing lipid peroxidation. These findings suggest that the autophagy-dependent and -independent functions of BECN1 play distinct roles in regulated cell death.

References


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Citations

Mar 19, 2020·Autophagy·Changfeng LiDaolin Tang
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Zhaoxin HuWei Zhang
Sep 11, 2020·Oxidative Medicine and Cellular Longevity·Yani WangJinwei Tian
Mar 31, 2019·Journal of Hematology & Oncology·Yanhua MouBin Li
Apr 24, 2020·Oxidative Medicine and Cellular Longevity·Lei ZhangYanzhang Li
Dec 10, 2020·Oxidative Medicine and Cellular Longevity·Xiang WeiDing-Sheng Jiang
Jan 7, 2021·Autophagy·Jingbo LiDaolin Tang
Mar 12, 2020·Cell Chemical Biology·Jiao LiuDaolin Tang
Mar 17, 2021·Free Radical Biology & Medicine·Zongbo WeiXingjun Fan
Mar 19, 2021·Journal of Neurochemistry·Yibo LiuSheng Chen
Apr 25, 2021·Cellular and Molecular Neurobiology·Renxuan HuangLiankun Sun
Jun 4, 2021·Signal Transduction and Targeted Therapy·Ruoxi ZhangDaolin Tang
May 20, 2021·Oxidative Medicine and Cellular Longevity·Ankita Sharma, Swaran Jeet Singh Flora
Jul 14, 2021·Open Biology·Zenghua ShengShufang Liang
Jan 23, 2020·Current Medicinal Chemistry·Shunqin ZhuWanhong Liu

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Methods Mentioned

BETA
transfection
biosensor
lipidation
immunoprecipitation

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