Becoming Stressed: Does the Age Matter? Reviewing the Neurobiological and Socio-Affective Effects of Stress throughout the Lifespan.

International Journal of Molecular Sciences
Aroa Mañas-OjedaEsther Castillo-Gómez

Abstract

Social and affective relations occur at every stage of our lives. Impairments in the quality of this "social world" can be exceptionally detrimental and lead to psychopathology or pathological behavior, including schizophrenia, autism spectrum disorder, affective disorders, social phobia or violence, among other things. Exposure to highly stressful or traumatic events, depending on the stage of life in which stress exposure occurs, could severely affect limbic structures, including the amygdala, and lead to alterations in social and affective behaviors. This review summarizes recent findings from stress research and provides an overview of its age-dependent effects on the structure and function of the amygdala, which includes molecular and cellular changes, and how they can trigger deviant social and affective behaviors. It is important to highlight that discoveries in this field may represent a breakthrough both for medical science and for society, as they may help in the development of new therapeutic approaches and prevention strategies in neuropsychiatric disorders and pathological behaviors.

References

Jan 1, 1992·Progress in Brain Research·B S McEwen
Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen
Sep 20, 1996·Annals of the New York Academy of Sciences·C S Widom, M G Maxfield
Sep 12, 1998·The American Journal of Psychiatry·R YehudaT Duvdevani
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
May 3, 2003·Child and Adolescent Psychiatric Clinics of North America·Bessel A van der Kolk
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gerd PoeggelKatharina Braun
Jun 26, 2004·Annual Review of Neuroscience·Thomas R Insel, Russell D Fernald
Apr 9, 2005·Annals of the New York Academy of Sciences·Richard Wilkinson
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rupshi MitraSumantra Chattarji
Aug 10, 2006·Stress : the International Journal on the Biology of Stress·Michał KraszpulskiA K Salm
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bea R H Van den BerghLieven Lagae
Jun 2, 2007·Brain Research·Paul R LeeJames I Koenig
Jun 16, 2007·Neurobiology of Aging·Marisa J RubinowJanice M Juraska
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rupshi Mitra, Robert M Sapolsky
Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaolong JiangHe Li
Nov 13, 2008·Nature Reviews. Neuroscience·Tomás PausJay N Giedd
Feb 18, 2010·Frontiers in Human Neuroscience·Nim Tottenham, Margaret A Sheridan
Apr 16, 2010·Annals of the New York Academy of Sciences·Ralph Adolphs
May 18, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Karen L JonesDavid Q Beversdorf
Jun 17, 2010·Brain Research Reviews·Arnaud CharilSuzanne King
Jul 8, 2010·Neurotoxicity Research·Eva M MarcoGiovanni Laviola
Aug 3, 2010·Biological Psychiatry·Tamara B FranklinIsabelle M Mansuy
Sep 30, 2010·Nature Neuroscience·Eric J Nestler, Steven E Hyman
Feb 2, 2011·Experimental Neurology·Stephen G Matthews, David I Phillips
Feb 24, 2011·Frontiers in Behavioral Neuroscience·Susana RoqueMargarida Correia-Neves
Apr 12, 2011·Current Pharmaceutical Design·M A Quera SalvaC Guilleminault
Aug 25, 2011·Brain & Development·Christina J Huppertz-KesslerJohannes Schenkel
Dec 16, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Frederick M BurkleUNKNOWN Task Force for Pediatric Emergency Mass Critical Care
Nov 22, 2011·Journal of Psychiatric Research·Emilio VareaJuan Nacher
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlis RainekiRegina M Sullivan
Sep 18, 2012·Behavioural Brain Research·Michael Lukas, Inga D Neumann
Sep 25, 2012·Trends in Neurosciences·Nuno Sousa, Osborne F X Almeida
Oct 11, 2012·Trends in Cognitive Sciences·Daniel P Kennedy, Ralph Adolphs

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Methods Mentioned

BETA
biopsies

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