PMID: 9556748Apr 29, 1998Paper

Bedside testing (SimpliRED) in the diagnosis of deep vein thrombosis. Evaluation of 250 patients

Investigative Radiology
J E WildbergerR W Günther

Abstract

The authors evaluate the sensitivity and specificity of a bedside test (SimpliRED) in the diagnosis of deep vein thrombosis compared with contrast phlebography. Two hundred fifty patients, referred for phlebography, underwent bedside testing for detection of deep vein thrombosis. Contrast phlebography was performed immediately afterward. SimpliRED provides a clearly visible agglutination of the patient's red blood cells in the presence of elevated levels of cross-linked fibrin derivative (D-dimer), which is specific for fibrin breakdown. In 82 (32.8%) patients, deep vein thrombosis was confirmed venographically. An abnormal D-Dimer test was found in 79 of the 82 patients with thrombosis (sensitivity: 96.3%). The three patients who were diagnosed falsely as normal on agglutinin testing, had venograms which showed only an isolated calf thrombosis in small muscle veins (< 2 cm in diameter) not requiring treatment. One hundred of 168 patients without venographic thrombosis were diagnosed correctly by SimpliRED (specificity: 59.5%). The positive predictive value was 53.7%; the negative predictive value was 96.8%. All thrombotic disorders in the leg that required further treatment were identified correctly. SimpliRED is a very sensit...Continue Reading

References

Sep 1, 1992·Thrombosis Research·M UdvardyK Rak
May 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·B BrennerD Rylatt
Jan 24, 1998·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·J E WildbergerD Vorwerk

❮ Previous
Next ❯

Citations

Jan 29, 2000·Annals of Emergency Medicine·J A KlineE G Israel
Jun 16, 2005·QJM : Monthly Journal of the Association of Physicians·S GoodacreF Morris
Dec 14, 2005·Ultrasound Quarterly·E James Andrews, Arthur C Fleischer
May 15, 2004·Clinical Chemistry·Steven W HeimJohn T Philbrick
Jul 17, 1999·Medizinische Klinik·C Ranke, H J Trappe
Jun 27, 2003·Annals of Emergency Medicine·UNKNOWN American College of Emergency Physicians (ACEP) Clinical Policies Committee, UNKNOWN ACEP Clinical Policies Subcommittee on Suspected Lower-Extremity Deep Venous Thrombosis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.