PMID: 37542Apr 11, 1979

Bedtime flurazepam and the human circadian rhythm of spontaneous motility

T J Crowley, M J Hydinger-Macdonald


Sixteen male students received bedtime placebo and flurazepam 30 mg at home in a counter-balanced double-blind, crossover design. For 24 h after each treatment the subjects' spontaneous motor activity was recorded each 15 min with an unobtrusive actometer, worn as the subjects attended classes. The circadian activity curves were submitted to cosinor analyses. The 24 h post-flurazepam activity was a mean of 15.1% lower than post-placebo activity (P less than 0.025). On the average, both the nocturnal through and the daytime peak of motility dropped; the latter change was greater, reducing by a mean of 19.4% the amplitude of the circadian rhythm of activity (P greater than 0.01). the timing, or phase, of the rhythm was not shifted. Although the drug did not consistently modify reports of subjective feelings on the Profile of Mood States (POMS), 13 subjects correctly discriminated drug from placebo sessions (P less than 0.05). A bedtime dose of 30 mg of flurazepam appears to significantly reduce spontaneous human motility that night and during the next day. Activity recording revealed an important residual, behavioral effect of the drug which was not reflected in POMS reports of subjective feelings, suggesting that activity record...Continue Reading


May 1, 1976·Clinical Pharmacology and Therapeutics·A KalesJ D Kales
Jun 1, 1975·British Journal of Clinical Pharmacology·M R Salkind, T Silverstone
Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·T J Crowley, M Hydinger
Dec 1, 1974·Archives of General Psychiatry·T J CrowleyI C Kaufman
Dec 1, 1973·Journal of Pharmaceutical Sciences·S A KaplanL Weissman
Sep 28, 1973·Psychopharmacologia·A J Bond, M H Lader
Sep 1, 1968·Journal of Pharmaceutical Sciences·N WatzmanJ P Buckley
Mar 1, 1963·Clinical Pharmacology and Therapeutics·H F FRASERA K THOMPSON


Jan 1, 1985·Psychopharmacology·T J CrowleyG Zerbe
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P Denise, M L Bocca
Mar 1, 1982·The International Journal of Neuroscience·J M Taub
Nov 1, 1987·British Journal of Clinical Pharmacology·A L LeemanS M Dobbs
Oct 1, 1980·British Journal of Clinical Pharmacology·I Oswald
Jan 1, 1990·Chronobiology International·A C BrownD P Redman

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