Bee venom acupuncture alleviates trimellitic anhydride-induced atopic dermatitis-like skin lesions in mice

BMC Complementary and Alternative Medicine
Bongjun SurD H Hahm

Abstract

Bee venom acupuncture (BVA), a novel type of acupuncture therapy in which purified bee venom is injected into the specific acupuncture point on the diseased part of the body, is used primarily for relieving pain and other musculoskeletal symptoms. In the present study, therapeutic potential of BVA to improve atopic dermatitis, a representative allergic dysfunction, was evaluated in the mouse model of trimellitic anhydride (TMA)-induced skin impairment. Mice were treated with 5% TMA on the dorsal flank for sensitization and subsequently treated with 2% TMA on the dorsum of both ears for an additional 12 days after a 3-day interval. From the 7(th) day of 2% TMA treatment, bilateral subcutaneous injection of BV (BV, 0.3 mg/kg) was performed daily at BL40 acupuncture points (located behind the knee) 1 h before 2% TMA treatment for 5 days. BVA treatment markedly inhibited the expression levels of both T helper cell type 1 (Th1) and Th2 cytokines in ear skin and lymph nodes of TMA-treated mice. Clinical features of AD-like symptoms such as ear skin symptom severity and thickness, inflammation, and lymph node weight were significantly alleviated by BV treatment. BV treatment also inhibited the proliferation and infiltration of T cells...Continue Reading

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Citations

Oct 6, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A-S BoisgardB Verrier
Jan 21, 2017·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali KomiRicardo D Zwiener
Oct 1, 2020·Toxins·Ting-Yen Lin, Ching-Liang Hsieh

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
transgenic
enzyme-linked immunosorbent assay
ELISA
PCR

Software Mentioned

DP2
BSW
SPSS
Primer3

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