PMID: 11312877Apr 21, 2001Paper

Beer consumption and changes in stability of human serum proteins

Journal of Agricultural and Food Chemistry
S GorinsteinO Martín-Belloso

Abstract

The aim of this study was to evaluate the influence of beer consumption (BC) on the functional and structural properties of human serum proteins (HSP). Thirty-eight volunteers (after coronary bypass) were divided into two groups: experimental (EG) and control (CG). Nineteen volunteers of the EG consumed 330 mL per day of beer (about 20 g of alcohol) for 30 consecutive days. The CG volunteers consumed mineral water instead of beer. Blood samples were collected from EG and CG patients before and after the experiment. Albumin (Alb), globulin (Glo), and methanol-precipitable proteins (MPP) from human serum were denatured with 8 M urea. Fluorescence and electrophoresis were employed in order to elucidate urea-induced conformational changes and structural behavior of proteins. The measured fluorescence emission spectra were used to estimate the stability of native and denatured protein fractions before and after BC. It was found that before BC the fractions most stable to urea denaturation were Glo, Alb, and MPP fractions. After BC in most of the beer-consuming patients (EG) some changes in native and denatured protein fractions were detected: a tendency to lower stability and minor structural deviations. These qualitative changes we...Continue Reading

References

Feb 15, 1988·Biochemical Pharmacology·B Halliwell
Mar 1, 1987·Analytical Biochemistry·D G WalbridgeL Brand
Sep 1, 1986·American Journal of Epidemiology·L A Friedman, A W Kimball
Apr 1, 1972·The American Journal of Clinical Nutrition·S P Lucia
Apr 20, 2001·Journal of Protein Chemistry·S GorinsteinO Martín-Belloso

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Citations

Dec 24, 2003·The Journal of Nutritional Biochemistry·Shela GorinsteinSimon Trakhtenberg
Mar 22, 2002·The Journal of Peptide Research : Official Journal of the American Peptide Society·S GorinsteinS Trakhtenberg
May 11, 2013·Journal of Photochemistry and Photobiology. B, Biology·Shubhashis DattaMintu Halder
Apr 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shan-Yang LinShun-Li Wang
Nov 1, 2012·Journal of Photochemistry and Photobiology. B, Biology·Daojin LiBaoming Ji
Dec 24, 2003·Addiction Biology·Shela Gorinstein, Simon Trakhtenberg

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