Beet root (Beta vulgaris) protects lipopolysaccharide and alcohol-induced liver damage in rat.

Toxicological Research
Bae-Hwan KimSuryun Jung

Abstract

The purpose of this study was to investigate the protective effects of beet root (Beta vulgaris var. rubra) in lipopolysaccharide (LPS) and alcohol induced liver damage. Beta vulgaris ethanol extract (BVEE) showed good antioxidant activity in the contents of polyphenol and flavonoid compounds, and the electron-donating ability and ABTS+ radical scavenging activity. As for anti-inflammatory effect in RAW 264.7 cells, inhibition rate of nitric oxide production was increased in dose dependent manner. In hepatotoxicity model induced by LPS and alcohol in rat, BVEE significantly decreased serum AST, ALT and γ-GTP concentrations in a dose-dependent manner. The histopathological changes after H&E staining showed that fat accumulation and inflammatory cell infiltration were decreased by BVEE. The collagen fibers around the central lobule observed by Masson's trichrome staining were also decreased by BVEE. In addition, as for the immunohistochemical staining and Transmission electron microscopy, BVEE improved morphological characteristics of damaged liver lesion. The increased mRNA expressions of NF-κB, MAPK1, MAPK3, CYP2E1, and α-SMA were significantly decreased in BVEE treated group. These results indicated that BVEE would have protec...Continue Reading

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Citations

Apr 13, 2021·Journal of Cancer Prevention·Mei Lan Tan, Shahrul Bariyah Sahul Hamid
Jun 3, 2021·International Journal of Molecular Sciences·Yeongkag KwonSeung Hyun Han

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Methods Mentioned

BETA
transmission electron microscopy
light microscopy
PCR

Software Mentioned

SPSS

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