Beetroot Juice Increases Human Muscle Force without Changing Ca2+-Handling Proteins

Medicine and Science in Sports and Exercise
J WhitfieldG P Holloway

Abstract

Dietary inorganic nitrate (NO3) supplementation improves skeletal muscle (SkM) contractile efficiency, and although rodent literature has suggested improvements in calcium handling or redox modifications as likely explanations, the direct mechanism of action in humans remains unknown. This study aimed to examine the effects of 7 d of beetroot juice (BRJ) supplementation on SkM contractile characteristics and function. Recreationally active males (n = 8) underwent transcutaneous electrical muscle stimulation of the vastus lateralis for the evaluation of contractile characteristics before and after 7 d of BRJ supplementation (280 mL·d, ~26 mmol NO3). An additional group of individuals (n = 8) followed the same supplementation protocol but underwent SkM biopsies pre- and post-supplementation for the determination of proteins associated with calcium handling via Western blotting, and the ratio of reduced/oxidized glutathione (GSH:GSSG), an indicator of cellular redox state, via high-performance liquid chromatography (HPLC). After supplementation, there was no change in maximal voluntary force production (602 ± 50 vs 596 ± 56 N) or electrically induced tetanic contractions. By contrast, force production was increased at 10 Hz electr...Continue Reading

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Citations

Mar 14, 2018·European Journal of Sport Science·Sinead T J McDonaghAndrew M Jones
Mar 17, 2018·Medicine and Science in Sports and Exercise·Andrew R Coggan
Mar 17, 2018·Medicine and Science in Sports and Exercise·Jamie WhitfieldGraham P Holloway
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May 5, 2018·Medicine and Science in Sports and Exercise·Neale A TillinChristopher J Tyler
Jul 13, 2018·Exercise and Sport Sciences Reviews·Andrew R Coggan, Linda R Peterson
Oct 10, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Trent StellingwerffJamie Whitfield
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Jul 28, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kate A Wickham, Lawrence L Spriet
Aug 5, 2020·Nature Metabolism·Mark Hargreaves, Lawrence L Spriet
Jul 1, 2020·European Journal of Sport Science·Kristin L JonvikJan-Willem van Dijk
Aug 1, 2020·Medicine and Science in Sports and Exercise·Andrew M JonesKristin L Jonvik
Feb 9, 2021·Critical Reviews in Food Science and Nutrition·Thiago Silveira AlvaresJuan Manuel Murias
Jan 19, 2021·The Journal of Physiology·Ravi A KumarLeonardo F Ferreira
Dec 6, 2021·Scandinavian Journal of Medicine & Science in Sports·Maysa V de SousaAndreas M Fritzen

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