PMID: 15229361Jul 2, 2004Paper

Behavior of metastatic and nonmetastatic breast tumors in old mice

Experimental Biology and Medicine
C GravekampRobert Reddick

Abstract

Breast cancer incidence and mortality increase with age. A better understanding of the biological behavior of metastatic and nonmetastatic breast tumors in older subjects may help to develop improved breast cancer therapies. In this study, we used syngeneic metastatic (4TO7cg) and nonmetastatic (64pT) mouse breast tumor models at three age levels to evaluate various characteristics that are considered to be important for effective anti-breast cancer immunotherapy. These included tumor size and growth, metastases, vascularization, gene expression levels of the tumor-associated antigen (TAA) Mage-b (homologous to human MAGE-B) in primary breast tumors and metastases, and the presence of CD4(+) and CD8(+) T cells in the inguinal lymph nodes at the site of the tumor. The primary breast tumors and metastases were generated by injection of mouse mammary tumor cell lines 4TO7cg or 64pT into a mammary fat pad of normal 3-, 9-, or 21/24-month old BALB/c mice. In the nonmetastatic breast tumor model, significantly smaller tumors were observed in old compared with young mice. This was associated with a significant increase in the percentage of CD8(+) T cells in inguinal lymph nodes and significantly higher Mage-b expression levels in the ...Continue Reading

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Citations

Mar 5, 2009·Cancer Immunology, Immunotherapy : CII·Claudia Gravekamp
Sep 10, 2014·Breast Cancer Research and Treatment·Omar M RashidKazuaki Takabe
Aug 5, 2006·Breast Cancer Research : BCR·Anna Fantozzi, Gerhard Christofori
Oct 1, 2005·Nature Reviews. Cancer·Vladimir N AnisimovAnatoly I Yashin
May 4, 2005·Breast Cancer Research and Treatment·Roza K SypniewskaClaudia Gravekamp
Jun 10, 2010·Future Oncology·Joseph Lustgarten
Feb 25, 2009·Cancer Immunology, Immunotherapy : CII·Joseph Lustgarten
Nov 25, 2014·Expert Opinion on Drug Metabolism & Toxicology·Omar M Rashid, Kazuaki Takabe

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