PMID: 2114509Jan 1, 1990Paper

Behavior of morphometric indices in pancreatic elastase-induced emphysema in rats

Lung
D H EidelmanJ G Martin

Abstract

Two morphometric indices, the destructive index (DI), a measure of alveolar wall destruction, and the proportion of destroyed alveolar attachments to the airways (AA), have been proposed as measures of early lung destruction in human smokers. The aim of this study was to compare DI and AA to the usual measure of airspace enlargement--the mean linear intercept (Lm)--in experimental emphysema. Porcine pancreatic elastase was administered intratracheally to 2 groups of Brown Norway rats (high-dose, n = 8, 1 IU/g body weight; low-dose, n = 4, 0.7 IU/g; control, n = 7). Total lung capacity (TLC), functional residual capacity (FRC) and pressure-volume curves were measured 3 weeks after administration of elastase. Lung elasticity was assessed by chord compliance (Cst). Administration of high-dose, but not low-dose, elastase led to significant increases in FRC and TLC. Cst significantly increased after high-dose elastase compared to controls (p less than 0.01). Lm increased after both low-dose and high-dose elastase compared to controls (p less than 0.01); DI and AA were increased only after high-dose elastase. Significant correlations were found between each morphometric index and Cst; the highest correlation was with AA. Behavior of ...Continue Reading

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Citations

Aug 15, 1996·Microscopy Research and Technique·B A Heemskerk-GerritsenA A Ten Have-Opbroek
Apr 3, 2003·Pulmonary Pharmacology & Therapeutics·Rubin M TuderEnid Neptune
May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joanne L WrightAndrew Churg
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·E CavarraG Lungarella
Sep 1, 1993·The American Review of Respiratory Disease·N Gonzalez MangadoM Paiva
May 27, 2006·American Journal of Respiratory and Critical Care Medicine·Tadashi SatoAkihito Ishigami
Sep 17, 2005·American Journal of Respiratory Cell and Molecular Biology·Yoshihiko ChibaMiwa Misawa
Apr 3, 2012·Biological & Pharmaceutical Bulletin·Bulin BailaShinya Minatoguchi
Feb 24, 2015·Expert Opinion on Drug Discovery·Concetta GardiPiero A Martorana
Oct 10, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Harry Karmouty QuintanaNicolau Beckmann
Jul 29, 2017·Journal of Applied Physiology·Annette RobichaudWayne Mitzner
Feb 23, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kengo KoikeAkihito Ishigami
Nov 13, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hiroaki MoriKuniaki Seyama

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