Behavior of unrepaired perimembranous ventricular septal defect in young adults

The American Journal of Cardiology
Veerle SouffletWerner Budts

Abstract

The number of adolescents and young adults with congenital heart defects, including ventricular septal defect (VSD), increases continuously. We evaluated the mid-term outcome of small and unclosed perimembranous VSDs (pmVSDs). All patients with a known unrepaired pmVSD at 16 years of age were selected from our database. The clinical, electrocardiographic, and echocardiographic changes between baseline and the latest follow-up examination were compared. A total of 220 patients (119 males, median age 18 years, interquartile range 7) could be included. During a median follow-up of 6 years (interquartile range 4, range 38), 2 patients died (1%; 1 from sudden death and 1 from end-stage heart failure). Endocarditis occurred in 8 patients (4%). One patient required pacemaker implantation (0.5%) and one required implantable cardioverter-defibrillator implantation (1%). Fifteen patients (7%) required a closing procedure. In 8 patients (4%), the pmVSD closed spontaneously. In the remaining 203 patients (93%), the QRS morphology changed in 5% and 1% lost sinus rhythm (p = 0.0001 and p = 0.015, respectively). The left ventricular ejection fraction and stroke volume index increased from 62 + or - 7% to 67 + or - 8% and from 41 + or - 11 to ...Continue Reading

References

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Citations

Dec 12, 2012·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M A CozijnsenB J Bouma
Aug 31, 2010·European Heart Journal·Helmut BaumgartnerUNKNOWN ESC Committee for Practice Guidelines (CPG)
Mar 8, 2013·PloS One·Christoph GerhardtUlrich Rüther
Jan 23, 2016·The American Journal of Cardiology·Jianming WangJian Yang
Apr 23, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Daniel S LeviWilliam Suh
Jul 13, 2016·International Journal of Cardiology·Charlien GabrielsWerner Budts
Feb 7, 2018·Cardiovascular Research·Maria Rita AssenzaFabio Naro
Sep 28, 2018·Congenital Heart Disease·Phong Teck LeeJu Le Tan
Sep 24, 2020·Journal of the American Heart Association·Marie MaagaardVibeke E Hjortdal
Oct 2, 2015·Proceedings·Jun ZhangWilliam C Roberts
Feb 17, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marie MaagaardVibeke E Hjortdal
Oct 19, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marie MaagaardVibeke E Hjortdal

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