PMID: 3215842Dec 1, 1988Paper

Behavioral activity during prolonged hypoxemia in fetal sheep

Journal of Applied Physiology
A D BockingS E White

Abstract

Experiments were conducted in unanesthetized, chronically catheterized pregnant sheep to determine the fetal behavioral response to prolonged hypoxemia produced by restricting uterine blood flow. Uterine blood flow was reduced by adjusting a vascular occluder placed around the maternal common internal iliac artery to decrease fetal arterial O2 content from 6.1 +/- 0.3 to 4.1 +/- 0.3 ml/dl for 48 h. Associated with the decrease in fetal O2 content, there was a slight increase in fetal arterial PCO2 and decrease in pH, which were both transient. There was an initial inhibition of both fetal breathing movements and eye movements but no change in the pattern of electrocortical activity. After this initial inhibition there was a return to normal incidence of both fetal breathing movements and eye movements by 16 h of the prolonged hypoxemia. These studies indicate that the chronically catheterized sheep fetus is able to adapt behaviorally to a prolonged decrease in arterial O2 content secondary to the restriction of uterine blood flow.

Citations

Mar 1, 1996·British Journal of Obstetrics and Gynaecology·P Johnson
Dec 1, 1995·Canadian Journal of Physiology and Pharmacology·A D BockingS B Hooper
May 2, 2009·The Journal of Physiology·Stephen J LeeLawrence D Longo
Mar 5, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erin V McGillickJanna L Morrison
Aug 1, 1995·Clinical and Experimental Pharmacology & Physiology·D W Walker
Jun 16, 2001·Journal of Applied Physiology·K KobayashiJ J Greer
Nov 20, 2002·Clinical Obstetrics and Gynecology·Frank A Manning
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Nov 28, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rajan PoudelJanna L Morrison
Dec 16, 2000·Clinical and Experimental Pharmacology & Physiology·R HardingG S Maritz
Nov 30, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·J M DenneyA C Sciscione
Nov 13, 2001·Clinical and Experimental Pharmacology & Physiology·E R LumbersK J Gibson
Mar 4, 2000·Clinical and Experimental Pharmacology & Physiology·D W WalkerI Nitsos
Nov 24, 2001·Brain Research. Developmental Brain Research·J L MorrisonW Riggs
Jan 14, 1998·Brain Research. Developmental Brain Research·S ReesR Harding
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alan D Bocking
Nov 5, 2005·Brain Research. Brain Research Reviews·David J MellorLaura Bennet

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