Behavioral activity of some novel aporphines in rats with 6-hydroxydopamine lesions of caudate or nucleus accumbens

European Journal of Pharmacology
E A JacksonP H Kelly

Abstract

The behavioral actions of some novel aporphines have been examined in rats with selective unilateral 6-hydroxydopamine (6OHDA)-induced destruction of nigrostriatal dopaminergic neurons, and in rats with bilateral 6OHDA-induced destruction of mesolimbic dopaminergic neurons. Dopaminomimetics such as apomorphine (APO) in these animal models elicit circling behavior and locomotor activity respectively. In animals with unilateral nigrostriatal lesions (-)-2,10,11-trihydroxy-N-n-propylnoraporphine (TNPA) and (-)-10,11-methylenedioxy-N-n-propylnoraporphine (MDO-NPA) elicited weak, but prolonged, contraversive circling, whereas (-)-2,10,11-trihydroxyaporphine (2-OH.APO) was inactive. In animals with bilateral destruction of mesolimbic dopaminergic neurons TNPA and MDO-NPA elicited a strong stimulation of locomotor activity, while 2-OH.APO was inactive. The results suggest that TNPA and MDO-NPA, but not 2-OH.APO, exert central dopaminomimetic effects in vivo. The results are also consistent with previous data indicating that N-propyl substitution of aporphines causes a relative enhancement of activity in animal models which emphasise effects at mesolimbic rather than striatal dopaminergic receptors.

References

Jan 15, 1978·European Journal of Pharmacology·C J Pycock, C D Marsden
May 5, 1978·Science·C A TammingaJ M Davis
Apr 1, 1977·Experimental Neurology·E S TolosaK E Dahl
Jan 1, 1976·European Journal of Pharmacology·R J MillerJ L Neumeyer
Mar 11, 1976·The New England Journal of Medicine·G C CotziasM Bell-Midura
Jan 1, 1970·The New England Journal of Medicine·G C CotziasI Mena
Jan 8, 1982·European Journal of Pharmacology·R J BaldessariniN S Kula
Dec 1, 1981·Biochemical Pharmacology·G W AranaM Harding

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Citations

Nov 14, 1983·Brain Research·E A Jackson, P H Kelly
Mar 1, 1991·Brain Research. Molecular Brain Research·H M Chao, B S McEwen
Nov 1, 1983·Brain Research Bulletin·E A Jackson, P H Kelly
Sep 1, 1983·Brain Research Bulletin·S L Hartgraves, P H Kelly
Mar 31, 1999·Psychoneuroendocrinology·C J McDougleL H Price
Jul 1, 1992·Comprehensive Psychiatry·D J SteinE Hollander
Jan 21, 2012·Pharmacology, Biochemistry, and Behavior·Catherine M ClaussenNachum Dafny

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