Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Tomasz Schneider, Ryszard Przewłocki

Abstract

Autism is a severe behavioral disorder characterized by pervasive impairments in social interactions, deficits in verbal and nonverbal communication, and stereotyped, repetitive patterns of behaviors and interests. Recently, a new rodent model of autism was created by exposure of rat fetuses to valproic acid (VPA) on the 12.5th day of gestation (VPA rats). The model has striking anatomical, pathological, and etiological similarities to human data; however, it has not been characterized behaviorally. In order to determine if VPA rats present behavioral aberrations observed in autism, their behavior was extensively evaluated in a battery of tests. The results of the present experiments demonstrate that VPA rats exhibit: (1) lower sensitivity to pain and higher sensitivity to nonpainful stimuli, (2) diminished acoustic prepulse inhibition, (3) locomotor and repetitive/stereotypic-like hyperactivity combined with lower exploratory activity, and (4) decreased number of social behaviors and increased latency to social behaviors. In addition, VPA rats showed delayed maturation, lower body weight, delayed motor development, and attenuated integration of a coordinated series of reflexes, delayed nest-seeking response mediated by olfacto...Continue Reading

References

Jan 1, 1979·Neuroscience and Biobehavioral Reviews·K A Roth, R J Katz
Nov 1, 1975·Animal Behaviour·J Altman, K Sudarshan
Mar 1, 1992·Brain & Development·T HashimotoY Kuroda
Jun 1, 1992·Alcoholism, Clinical and Experimental Research·J L Nanson
Aug 1, 1989·Neuropediatrics·T HashimotoY Kuroda
Mar 1, 1987·Pediatric Neurology·D L RossR Hitzemann
Jan 1, 1988·American Journal of Medical Genetics·H H ArdingerE J Lammer
Oct 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P E BinkerdA G Hendrickx
Sep 1, 1988·Biological Psychiatry·G R GaffneyS Minchin
Jun 1, 1985·Neurology·M Bauman, T L Kemper
May 1, 1971·Physiology & Behavior·E H Gregory, D W Pfaff
Sep 1, 1968·Archives of General Psychiatry·E R RitvoS La Fanchi
Jun 7, 1968·Acta Neuropathologica·S M Sumi, H Hager
Jun 1, 1980·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·A J Ayres, L S Tickle
Nov 1, 1982·Physiology & Behavior·R J Niesink, J M van Ree
Feb 1, 1995·Journal of Autism and Developmental Disorders·T HashimotoY Kuroda
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
May 2, 1994·The Science of the Total Environment·S E ChiaB H Heng
Apr 1, 1994·Developmental Medicine and Child Neurology·K StrömlandC Gillberg
Jun 24, 1996·The Journal of Comparative Neurology·P M RodierJ Romano
Mar 1, 1997·Reproductive Toxicology·P M RodierV J Croog
Apr 1, 1997·Current Opinion in Neurobiology·E Courchesne
May 1, 1997·Neuroscience and Biobehavioral Reviews·L J VanderschurenJ M Van Ree
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·P TeitelbaumR G Maurer
Apr 27, 1999·Brain Research. Cognitive Brain Research·N S HarrisC Lord
Jul 28, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A G CazzulloA Panerai
Jan 19, 2000·Journal of Autism and Developmental Disorders·M M Bristol-Power, G Spinella
Jan 19, 2000·Journal of Autism and Developmental Disorders·P A FilipekF R Volkmar
Jul 7, 2000·Journal of Medical Genetics·S J MooreJ C Dean
Feb 15, 2001·Frontiers in Bioscience : a Journal and Virtual Library·G Allen, E Courchesne
Mar 27, 2001·Developmental Medicine and Child Neurology·G WilliamsJ H Hersh
Apr 21, 2001·Biological Psychiatry·K Pierce, E Courchesne
Dec 6, 2001·Nature Reviews. Genetics·S E Folstein, B Rosen-Sheidley
Jan 5, 2002·Developmental Medicine and Child Neurology·N Bescoby-ChambersG Bates
Jun 22, 2002·Brain : a Journal of Neurology·Grainne M McAlonanDeclan G M Murphy
Jul 27, 2002·Molecular Psychiatry·T L Kemper, M L Bauman
Jul 27, 2002·Molecular Psychiatry·E Courchesne
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·R CeponieneK Yaguchi

❮ Previous
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Citations

Dec 7, 2010·Biological Psychiatry·Michael J GandalSteven J Siegel
Sep 24, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ori S CohenSandra M Mooney
Mar 12, 2009·Nature Reviews. Neuroscience·Barbara L ThompsonGregg D Stanwood
Sep 13, 2007·Molecular Psychiatry·S S Moy, J J Nadler
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kamila MarkramHenry Markram
Sep 30, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Rodney R Dietert, Janice M Dietert
Mar 21, 2007·Annual Review of Public Health·Craig J NewschafferGayle C Windham
Oct 19, 2006·Journal of Biomedicine & Biotechnology·John D Doherty
May 26, 2012·Developmental Neuroscience·Stacey ReynoldsDarragh P Devine
Sep 13, 2012·PloS One·Matthew R Sarkisian, Dorit Siebzehnrubl
Jan 2, 2014·Pathology Research International·Taylor ChomiakBin Hu
Jul 16, 2013·Psychopharmacology·Marija M Petrinovic, Basil Künnecke
Aug 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tania RinaldiHenry Markram
Feb 13, 2016·Neuroscience Letters·Megan W BourassaRajiv R Ratan
Jan 1, 2011·Emerging Health Threats Journal·Rodney R DietertJamie C Dewitt
Feb 4, 2016·Food & Nutrition Research·Edson Luck T GonzalesChan Young Shin
Feb 12, 2013·Neurotoxicology and Teratology·Florence I RoulletJane A Foster
May 23, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tetsuo OgawaSeiji Shioda

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