PMID: 6112768Jan 1, 1981Paper

Behavioral and biochemical studies of the scopolamine-induced reversal of neuroleptic activity

Psychopharmacology
M G OndrusekGeorge R Breese

Abstract

Scopolamine reversed the reduction in avoidance responding caused by spiperone and antagonized the inhibitory effects of spiperone on the behavioral actions of d-amphetamine or apomorphine. Scopolamine-induced locomotor activity was greater in 6-hydroxydopamine (6-OHDA)-treated animals than in controls. This increase was prevented by administration of alpha-methyltyrosine, but not by inhibition of dopamine-beta-hydroxylase, indicating that this action of scopolamine was associated with presynaptic dopaminergic fibers. Therefore, the possibility that pre-synaptic dopaminergic function was the locus of the antagonism of spiperone by scopolamine was examined using drug interaction studies in 6-OHDA-treated rats. However, when 6-OHDA-treated rats were given alpha-methyltyrosine, scopolamine still reversed the spiperone blockade of apomorphine-induced locomotion. Although these data provided evidence for a post-synaptic action for this cholinergic blocking agent, scopolamine affected neither dopamine-stimulated adenylate cyclase activity nor 3H-spiperone binding in vitro. Furthermore, scopolamine did not alter the level of specific 3H-spiperone binding found in brain after in vivo administration. This suggests that the post-synaptic...Continue Reading

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Citations

Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·K L PrestonC R Schuster
Nov 1, 1985·Pharmacology, Biochemistry, and Behavior·K L PrestonL S Seiden
Jun 1, 1985·Pharmacology, Biochemistry, and Behavior·G R BreeseR A Mueller
Jun 1, 1994·Pharmacology, Biochemistry, and Behavior·N A DarmaniC F Gerdes
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J N Joyce
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·A RobertsonC MacDonald
Mar 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·E MotlesC Acuña
Apr 1, 1997·Reviews in the Neurosciences·L E RueterB L Jacobs
Sep 1, 1986·The Australian and New Zealand Journal of Psychiatry·F K Judd, G D Burrows
Dec 1, 1986·The Australian and New Zealand Journal of Psychiatry·A RoyD Pickar
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·J BruhwylerM Mercier
Sep 24, 2008·Handbook of Clinical Neurology·Richard B Mailman, Xuemei Huang

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