Behavioral and cardiovascular changes in the chronic mild stress model of depression

Physiology & Behavior
Angela J GrippoAlan Kim Johnson

Abstract

Depression is a multifaceted psychological disorder that involves changes in behavior, neuroendocrine function, and physiological responses. The present study investigated multiple behavioral and cardiovascular consequences in the chronic mild stress (CMS) rodent model of depression. Rats were exposed to 4 weeks of CMS followed by 4 weeks of a stress-free recovery period. Sucrose intake, a measure of anhedonia, and spontaneous locomotor activity were measured weekly throughout the study, and cardiovascular function tests were conducted at the completion of the protocol. The results indicate that CMS results in anhedonia and reduced locomotor activity, as well as elevated heart rate (HR), reduced HR variability, and elevated sympathetic cardiac tone. The behavioral effects of CMS recovered to baseline (prestress) levels during the recovery period; however, cardiovascular changes were observed following the recovery of sucrose intake and activity levels. The present findings suggest that behavioral changes that are indicative of anhedonia and locomotor alterations associated with depression are dissociable from long-term cardiovascular changes induced by CMS.

References

Mar 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J L MoreauW E Haefely
Jan 1, 1990·Annals of the New York Academy of Sciences·H Y Meltzer
Jan 1, 1987·Journal of Psychiatric Research·H W Lahmeyer, S N Bellur
May 1, 1972·Archives of Internal Medicine·W A GreeneA J Moss
Jan 1, 1984·Psychopharmacology·P Willner
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R J KatzB J Carroll
Apr 1, 1993·Immunology Today·E T Cunningham, E B De Souza
May 1, 1996·Pharmacology, Biochemistry, and Behavior·Z GorkaM Papp
Nov 4, 1996·Journal of Affective Disorders·G Loas
Feb 15, 1997·Biological Psychiatry·S CheetaP Willner

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Citations

Jul 15, 2011·The Journal of Membrane Biology·Nigar YilmazIbrahim Eren
Jul 25, 2007·Cardiovascular Toxicology·William H RowanWilliam P Watkinson
Oct 5, 2013·Neurochemistry International·Yanli XingHiroshi Kurihara
Oct 27, 2004·Physiology & Behavior·Vera M A FarahMariana Morris
Apr 2, 2003·Neuroscience and Biobehavioral Reviews·Angela J Grippo, Alan Kim Johnson
Jun 14, 2006·Behavioral Neuroscience·Michael J MorrisAlan Kim Johnson
May 16, 2008·Psychosomatic Medicine·Angela J GrippoAlan Kim Johnson
Jul 19, 2008·Journal of Applied Physiology·Julia A MoffittAlan Kim Johnson
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason J RadleySara A Romig-Martin
Nov 5, 2013·Frontiers in Neuroendocrinology·Mary K Holder, Jeffrey D Blaustein
Feb 5, 2014·Brain Research·Marco Antônio Peliky FontesEugene Nalivaiko
Jun 8, 2014·Physiology & Behavior·Jessica Saalfield, Linda Spear
Jul 12, 2013·BMC Psychiatry·Yiming WangMichael Berk
Sep 10, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Sean J CollobyAlan J Thomas
Jan 21, 2006·Stress : the International Journal on the Biology of Stress·Jakub DobruchEwa Szczepanska-Sadowska
Jan 23, 2016·Translational Psychiatry·S AslaniJ A Palha
Jan 1, 2009·Physiological and Biochemical Zoology : PBZ·Nicole E CyrL Michael Romero
Feb 10, 2011·Physiology & Behavior·Kristen A StedenfeldAlan F Sved
Apr 13, 2010·Neurobiology of Disease·Chad E BeyerGarth T Whiteside
Jun 9, 2009·International Journal of Cardiology·Dimitris TousoulisChristodoulos Stefanadis
Jun 3, 2008·Physiology & Behavior·Michael J MorrisAlan Kim Johnson
Aug 31, 2007·Physiology & Behavior·Shuwen LiangLouis N Irwin
Apr 27, 2007·Pharmacology, Biochemistry, and Behavior·Clifford C Michaels, Stephen G Holtzman
Nov 17, 2006·Physiology & Behavior·Angela J GrippoStephen W Porges
May 2, 2013·Journal of Neuroscience Research·Prasanth S AriyannurAryan M A Namboodiri
Oct 15, 2014·Clinical and Experimental Pharmacology & Physiology·Agnieszka Cudnoch-JedrzejewskaAgnieszka Wsol

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